School of Dentistry, Universidade de São Paulo, Av. Prof. Lineu Prestes, 2227, São Paulo, SP, 05508-000, Brazil.
School of Medicine, Universidade Federal Do Maranhão, Imperatriz, MA, Brazil.
Eur Arch Otorhinolaryngol. 2023 Aug;280(8):3891-3896. doi: 10.1007/s00405-023-08023-8. Epub 2023 May 25.
It has been hypothesised that secretory carcinoma of the salivary gland (SCsg) might have a lactational-like differentiation. Therefore, we aimed to assess the immunoexpression of breast hormonal receptors and milk-related proteins in cases of SCsg and other salivary gland tumours with prominent secretory activity.
Immunohistochemistry against prolactin and growth hormone receptors, lactoferrin, human milk fat globule 1, MUC 1 and MUC4 was performed in twelve cases of SCsg and 47 other salivary gland tumours.
Most cases of SCsg were negative for prolactin and growth hormone receptors. All cases of SCsg showed enhanced membranous-cytoplasmic staining for human milk fat globule 1, a pattern seen in other tumour groups. Only SCsg showed widespread strong staining for lactoferrin, concomitantly in the cell compartment and secretion. The other positive tumour types exhibited restricted staining. MUC1 and MUC4 showed no distinct pattern of expression.
Although SCsg failed to demonstrate a complete lactational-like differentiation, lactoferrin showed a distinctive expression pattern in SCsg compared to other tumour types, which makes it a good marker to help in its differential diagnosis.
有人假设唾液腺癌（SCsg）可能具有哺乳期样分化。因此，我们旨在评估在具有明显分泌活性的 SCsg 和其他唾液腺肿瘤病例中乳腺激素受体和与乳汁相关的蛋白质的免疫表达。
对十二例 SCsg 和 47 例其他唾液腺肿瘤进行针对催乳素和生长激素受体、乳铁蛋白、人乳脂肪球 1、MUC1 和 MUC4 的免疫组织化学染色。
大多数 SCsg 病例对催乳素和生长激素受体呈阴性。所有 SCsg 病例均显示人乳脂肪球 1 的膜细胞质染色增强，这种模式见于其他肿瘤组。只有 SCsg 显示乳铁蛋白广泛强染色，同时存在于细胞区室和分泌中。其他阳性肿瘤类型显示有限的染色。MUC1 和 MUC4 没有明显的表达模式。
尽管 SCsg 未能表现出完全的哺乳期样分化，但乳铁蛋白在 SCsg 与其他肿瘤类型相比表现出独特的表达模式，使其成为帮助鉴别诊断的良好标志物。
