Sasaki Eiichi, Terada Hoshino, Oishi Naoki, Iwakoshi Akari, Masago Katsuhiro, Matsushita Hirokazu, Yamamoto Hidetaka, Hanai Nobuhiro, Tateyama Hisashi
Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-Ku, Nagoya, Aichi, 464-8681, Japan.
Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Virchows Arch. 2024 Jun;484(6):945-950. doi: 10.1007/s00428-023-03701-8. Epub 2023 Nov 13.
Recently, cases of carcinoma showing thymus-like differentiation (CASTLE) occurring in major salivary glands have been identified. To assess the diagnostic value of CD5 immunohistochemistry in distinguishing salivary CASTLE from other types of salivary gland tumors, we evaluated CD5 expression in 109 salivary gland tumors, encompassing 23 different histological types, including salivary CASTLE. In addition, we reviewed 10 previously reported cases of salivary CASTLE. Most salivary CASTLE cases (10/11, 91%) showed strong CD5 expression. In contrast, 104 of 108 (96%) non-salivary CASTLE tumors were negative for CD5, while the remaining four tumors (3.7%), all of which were histologically Warthin tumors, showed focal positivity for CD5 with weak to moderate intensity. In conclusion, the findings in this study support the potential use of CD5 immunohistochemistry for distinguishing salivary CASTLE from other histological types of salivary gland tumors. Aberrant CD5 expression in this tumor may be linked to the tumor microenvironment.
最近，已发现主要涎腺中出现具有胸腺样分化的癌（CASTLE）病例。为评估CD5免疫组化在鉴别涎腺CASTLE与其他类型涎腺肿瘤中的诊断价值，我们评估了109例涎腺肿瘤中CD5的表达情况，这些肿瘤涵盖23种不同组织学类型，包括涎腺CASTLE。此外，我们回顾了10例先前报道的涎腺CASTLE病例。大多数涎腺CASTLE病例（10/11，91%）显示CD5强表达。相比之下，108例非涎腺CASTLE肿瘤中有104例（96%）CD5阴性，其余4例肿瘤（3.7%）均为组织学上的沃辛瘤，显示CD5局灶性阳性，强度为弱至中度。总之，本研究结果支持CD5免疫组化在鉴别涎腺CASTLE与其他组织学类型涎腺肿瘤中的潜在应用。该肿瘤中异常的CD5表达可能与肿瘤微环境有关。
