Cheng Zhaoping, Chen Li, Wang Ximing, Wang Ying, Zhao Minjie, Zan Keyu, Liu Wen, Cui Xiao, Chai Leiying, Ge Min, Li Kun, Duan Yanhua
Department of Nuclear Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, 250014, People's Republic of China.
Department of Ultrasound, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People's Republic of China.
Insights Imaging. 2023 May 25;14(1):100. doi: 10.1186/s13244-023-01446-1.
Respiratory motion during PET acquisition may result in image blurring and resolution loss, reduced measurement of radiotracer uptake, and consequently, inaccurate lesion quantification and description. With the introduction of the total-body PET system, short-time PET acquisition is feasible due to its high sensitivity and spatial resolution. The purpose of this study was to evaluate the additional value of 20-s breath-hold (BH) lung PET in patients with stage IA pulmonary adenocarcinoma.
Forty-seven patients with confirmed stage IA pulmonary adenocarcinoma were enrolled in this retrospective study. All patients underwent a 300-s FB whole-body PET, followed by a BH lung PET. The SUV, TBR of the lesions and the percentage difference in nodule SUV (%ΔSUV) and TBR (%ΔTBR) between the two acquisitions was also calculated. The lesions were further divided by distance from pleura for subgroup analysis. The lesion detectability on PET images was the percentage of FDG-positive lesions.
Among 47 patients, the BH lung PET images identified all lung nodules, and there was a significant difference in overall nodule SUV and TBR between BH PET and FB PET (both p < 0.01). The %ΔSUV and %ΔTBR were significantly higher in nodules adjacent to pleura (≤ 10 mm in distance) than those away from pleura (both p < 0.05). The lesion detectability of BH lung PET was significantly higher than that of FB PET (p < 0.01).
BH PET acquisition is a practical way to minimize motion artifacts in PET which has the potential to improve lesion detection for stage IA pulmonary adenocarcinoma.
BH PET acquisition is a practical way to minimize motion artifacts in PET which has the potential to improve lesion detection for stage IA pulmonary adenocarcinoma.
PET采集过程中的呼吸运动可能导致图像模糊和分辨率降低，放射性示踪剂摄取量测量减少，进而导致病变定量和描述不准确。随着全身PET系统的引入，由于其高灵敏度和空间分辨率，短时间PET采集是可行的。本研究的目的是评估20秒屏气（BH）肺PET在IA期肺腺癌患者中的附加价值。
47例确诊为IA期肺腺癌的患者纳入本回顾性研究。所有患者均接受300秒自由呼吸（FB）全身PET检查，随后进行BH肺PET检查。还计算了两次采集之间病变的SUV、TBR以及结节SUV（%ΔSUV）和TBR（%ΔTBR）的百分比差异。根据病变与胸膜的距离进一步分组进行亚组分析。PET图像上病变的可检测性为FDG阳性病变的百分比。
47例患者中，BH肺PET图像识别出了所有肺结节，BH PET和FB PET之间的总体结节SUV和TBR存在显著差异（均p<0.01）。与胸膜距离≤10mm的结节的%ΔSUV和%ΔTBR显著高于远离胸膜的结节（均p<0.05）。BH肺PET的病变可检测性显著高于FB PET（p<0.01）。
BH PET采集是一种减少PET运动伪影的实用方法，有可能改善IA期肺腺癌的病变检测。
BH PET采集是一种减少PET运动伪影的实用方法，有可能改善IA期肺腺癌的病变检测。
