Gariot P, Genton P, Barrat E, Foliguet B, Drouin P, Pointel J P, Gross P, Debry G
J Hepatol. 1986;2(3):495-503. doi: 10.1016/s0168-8278(86)80061-7.
We obtained liver biopsies in 4 patients with type IIA and 7 patients with type IIB hyperlipoproteinemia, and also in 7 healthy controls. A morphometric analysis of liver tissue was carried out by light and electron microscopy. Structural alterations of the hepatocyte and its organelles in type IIA and IIB hyperlipoproteinemia seem to fall into different categories: smaller nuclei, enlarged peroxisomes and altered mitochondria are found in both types of hyperlipoproteinemia, while an increase in the volume of hepatocytes is found only in type IIA. The enlargement of liver peroxisomes in untreated hyperlipoproteinemia is noteworthy, since it has been considered as a marker of the liver toxicity of lipid-lowering drugs.
我们对4例IIA型和7例IIB型高脂蛋白血症患者以及7名健康对照者进行了肝脏活检。通过光镜和电镜对肝组织进行了形态计量分析。IIA型和IIB型高脂蛋白血症中肝细胞及其细胞器的结构改变似乎分为不同类别：两种类型的高脂蛋白血症均可见细胞核变小、过氧化物酶体增大和线粒体改变，而仅在IIA型中发现肝细胞体积增大。未经治疗的高脂蛋白血症中肝脏过氧化物酶体增大值得关注，因为它被视为降脂药物肝脏毒性的标志物。
