Cheng Yuanpei, Feng Hao, Mu Junhan, Chen Jialin, Wu Han
Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, China.
Department of Orthopedics Trauma and Sports Medicine, The Affiliated Hospital of Hebei University, Baoding, China.
Front Med (Lausanne). 2023 May 9;10:1175787. doi: 10.3389/fmed.2023.1175787. eCollection 2023.
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a rare musculoskeletal disease characterized by dermatological and osteoarticular lesions. However, SAPHO syndrome is difficult to be diagnosed due to the rarity and complexity. Additionally, there is no standard treatment for SAPHO syndrome based on limited experience. Percutaneous vertebroplasty (PVP) has rarely been reported to treat SAPHO syndrome. We reported a 52-year-old female patient who had a sex-month history of back pain. Palmoplantar pustulosis appeared on the hands and feet. Vertebral destruction was observed on computed tomography (CT) scanning. Laboratory examination showed that erythrocyte sedimentation rate (ESR) and C-reactive protein were elevated. Finally, the patient was diagnosed with SAPHO syndrome and treated with PVP. After the surgery, the back pain was significantly relieved. In this study, we mainly discussed the treatment methods of SAPHO syndrome, and provided a potential treatment for SAPHO syndrome, especially with vertebral destruction, kyphosis, and even pathological fractures.
滑膜炎、痤疮、脓疱病、骨肥厚和骨炎（SAPHO）综合征是一种罕见的肌肉骨骼疾病，其特征为皮肤和骨关节病变。然而，由于其罕见性和复杂性，SAPHO综合征难以诊断。此外，基于有限的经验，对于SAPHO综合征尚无标准治疗方法。经皮椎体成形术（PVP）治疗SAPHO综合征的报道很少。我们报告了一名52岁女性患者，她有6个月的背痛病史。手足出现掌跖脓疱病。计算机断层扫描（CT）显示椎体破坏。实验室检查显示红细胞沉降率（ESR）和C反应蛋白升高。最终，该患者被诊断为SAPHO综合征并接受了PVP治疗。手术后，背痛明显缓解。在本研究中，我们主要讨论了SAPHO综合征的治疗方法，并为SAPHO综合征，尤其是伴有椎体破坏、脊柱后凸甚至病理性骨折的情况提供了一种潜在的治疗方法。
