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毛发石三联征:长发公主综合征、严重营养不良和脑静脉血栓形成。

A Triad of Trichobezoar: Rapunzel Syndrome, Severe Malnutrition, and Cerebral Venous Thrombosis.

作者信息

Shastri Minal, Raval Darshankumar M, Rathod Vaishnavi M, Mallik Shashwat, Khan Shahin

机构信息

Internal Medicine, Government Medical College, Baroda, Vadodara, IND.

出版信息

Cureus. 2023 Apr 23;15(4):e38016. doi: 10.7759/cureus.38016. eCollection 2023 Apr.

Abstract

Trichobezoar is a rare condition almost exclusively seen in young females presenting with non-specific abdominal complaints and a history of psychiatric illness. In most patients, it is confined within the stomach; however, in some severe cases, it extends through the pylorus into the duodenum, jejunum, ileum, or even colon, known as Rapunzel syndrome. Conventional treatment includes laparotomy and psychiatric counseling to prevent relapses. We report the case of an 18-year-old female with no previous history of medical or psychiatric illness who presented with chief complaints of upper abdominal pain, nausea, occasional vomiting for the last six months, and generalized edema for the last three days. On examination, pallor, anasarca, and a palpable abdominal lump were present. On blood investigations, severe malnutrition was seen in the form of severe iron deficiency anemia and severe protein deficiency. Radiological evaluation revealed a large trichobezoar on the CT abdomen and endoscopy, whereas CT venography of the brain, done for persistent headache, showed hyperdense thrombi in the cortical veins. Exploratory laparotomy was done to remove trichobezoar, followed by medical management of malnutrition, cerebral venous thrombosis (CVT) with anticoagulants, and psychiatric counseling for trichobezoar. The association between trichobezoar, malnutrition, and CVT in our case is a further area of research.

摘要

毛发石是一种罕见病症,几乎仅见于年轻女性,她们表现出非特异性腹部症状且有精神疾病史。在大多数患者中,毛发石局限于胃内;然而,在一些严重病例中,它会通过幽门延伸至十二指肠、空肠、回肠,甚至结肠,即所谓的长发公主综合征。传统治疗方法包括剖腹手术和心理咨询以防止复发。我们报告一例18岁女性病例,她既往无内科或精神疾病史,主要症状为上腹部疼痛、恶心、近六个月偶尔呕吐,以及近三天全身水肿。检查发现面色苍白、全身水肿,可触及腹部肿块。血液检查显示存在严重营养不良,表现为严重缺铁性贫血和严重蛋白质缺乏。影像学评估显示腹部CT和内镜检查发现一个大的毛发石,而因持续性头痛进行的脑部CT静脉造影显示皮质静脉有高密度血栓。进行了剖腹探查以取出毛发石,随后对营养不良、脑静脉血栓形成(CVT)采用抗凝药物进行药物治疗,并对毛发石进行心理咨询。我们病例中毛发石、营养不良和CVT之间的关联是一个进一步的研究领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2520/10207979/461e16e65daf/cureus-0015-00000038016-i01.jpg

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