Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Biomed Res Int. 2023 May 16;2023:4711275. doi: 10.1155/2023/4711275. eCollection 2023.
Previous studies reported a relationship between thyroid-stimulating hormone (TSH) and low-density lipoprotein cholesterol (LDL-C) levels. In this study, we aim to evaluate the impact of TSH levels on lipid profile in patients with familial hypercholesterolemia (FH) and euthyroid state. Patients were selected from the Isfahan FH registry. The Dutch Lipid Clinic Network (DLCN) criteria are used to detect FH. Patients were classified into no FH, possible FH, probable FH, and definite FH groups based on the DLCN scores. Patients with any cause of secondary hyperlipidemia, including hypothyroidism, were excluded from this study. The study group consisted of 103 patients with possible FH, 25 patients with definite FH, and 63 individuals with no FH. The mean TSH and LDL-C levels among participants were 2.10 ± 1.22 mU/l and 142.17 ± 62.56 mg/dl, respectively. No positive or negative correlation was found between serum TSH and total cholesterol ( value = 0.438), high-density lipoprotein cholesterol ( = 0.225), triglycerides ( value = 0.863), and LDL-C ( value = 0.203). We found no correlation between serum TSH levels and lipid profiles in euthyroid patients with FH.
先前的研究报告指出，促甲状腺激素（TSH）与低密度脂蛋白胆固醇（LDL-C）水平之间存在关联。在这项研究中，我们旨在评估 TSH 水平对甲状腺功能正常的家族性高胆固醇血症（FH）患者血脂谱的影响。患者从伊斯法罕 FH 注册中心中选择。荷兰血脂临床网络（DLCN）标准用于检测 FH。根据 DLCN 评分，患者被分为无 FH、可能 FH、可能 FH 和确定 FH 组。本研究排除了任何继发性高脂血症的患者，包括甲状腺功能减退症。研究组包括 103 例可能 FH、25 例确诊 FH 和 63 例无 FH 患者。参与者的平均 TSH 和 LDL-C 水平分别为 2.10 ± 1.22 mU/l 和 142.17 ± 62.56 mg/dl。血清 TSH 与总胆固醇（ 值= 0.438）、高密度脂蛋白胆固醇（ 值= 0.225）、甘油三酯（ 值= 0.863）和 LDL-C（ 值= 0.203）之间未发现正相关或负相关。我们发现甲状腺功能正常的 FH 患者的血清 TSH 水平与血脂谱之间没有相关性。
