Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu, P. R. China.
Horm Metab Res. 2021 Jan;53(1):32-40. doi: 10.1055/a-1191-7953. Epub 2020 Jun 23.
The aim of the work was to investigate the correlation between serum TSH (thyrotropin) levels within normal range and serum lipids. A total of 1962 subjects with normal thyroid function were enrolled. The subjects were divided into four groups according to the quartiles of serum normal TSH levels, [Q (0.27-1.68) mIU/l, Q (1.69-2.35) mIU/l, Q (2.36-3.07) mIU/l, and Q (3.08-4.20) mIU/l]. The effect of serum normal TSH levels on serum lipid profiles of different age or gender was analyzed. The total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels of the Q group and TG levels of the Q group were higher than those of the Q group in youth (p <0.05). The TC levels of the Q group were higher than those of the Q group in middle age (p <0.05). The LDL-C levels of middle age or elderly were higher than those of youth at the same TSH levels (p <0.05), while the TC levels of middle age were higher than those of youth in Q, Q, or Q group (p <0.05), and the TC and HDL-C levels of elderly were higher than those of youth in the Q group (p <0.05). The TG levels of the Q group were higher than those of Q group in males (p <0.05). The LDL-C levels of the Q group were higher than those of the Q group in females (p <0.05). In conclusion, the normal serum TSH levels were found to be closely related to serum lipid profiles, and with increasing TSH levels, serum lipids levels increased gradually.
本研究旨在探讨血清促甲状腺激素（TSH）水平在正常范围内与血清脂质之间的相关性。共纳入 1962 例甲状腺功能正常的受试者。根据血清正常 TSH 水平的四分位区间，将受试者分为 4 组[Q（0.27-1.68）mIU/L、Q（1.69-2.35）mIU/L、Q（2.36-3.07）mIU/L 和 Q（3.08-4.20）mIU/L]。分析了血清正常 TSH 水平对不同年龄或性别人群血清脂质谱的影响。Q 组的总胆固醇（TC）、三酰甘油（TG）和低密度脂蛋白胆固醇（LDL-C）水平以及青年 Q 组的 TG 水平均高于 Q 组（p<0.05）。Q 组的 TC 水平高于中年 Q 组（p<0.05）。相同 TSH 水平下，中年和老年的 LDL-C 水平高于青年（p<0.05），而 Q、Q 或 Q 组中年的 TC 水平高于青年（p<0.05），且 Q 组老年的 TC 和高密度脂蛋白胆固醇（HDL-C）水平高于青年（p<0.05）。Q 组男性的 TG 水平高于 Q 组（p<0.05）。Q 组女性的 LDL-C 水平高于 Q 组（p<0.05）。总之，正常血清 TSH 水平与血清脂质谱密切相关，随着 TSH 水平的升高，血清脂质水平逐渐升高。
