功能筛选优化身高全基因组关联研究位点。
Functional screens refine height GWAS loci.
作者信息
Ackert-Bicknell Cheryl L
机构信息
Colorado Program for Musculoskeletal Research, Department of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
出版信息
Cell Genom. 2023 May 10;3(5):100325. doi: 10.1016/j.xgen.2023.100325.
Genome-wide association studies (GWASs) have demonstrated the complexity of human height. Baronas et al. used a high-throughput CRISPR screen to identify genes that participate in growth plate chondrocyte maturation as a functional follow-up and validation screen to refine loci and establish causality after GWASs.
全基因组关联研究（GWAS）已经证明了人类身高的复杂性。巴罗纳斯等人进行了一项高通量CRISPR筛选，以识别参与生长板软骨细胞成熟的基因，作为功能后续研究和验证筛选，以完善基因座并在GWAS之后确定因果关系。
Zotero 插件