Singh Himanshu
Department of Oral and Maxillofacial Pathology and Oral Microbiology, Index Institute of Dental Sciences, Indore, Madhya Pradesh, India.
Glob Med Genet. 2023 May 23;10(2):79-86. doi: 10.1055/s-0043-57247. eCollection 2023 Jun.
Breast cancer is a multifactor, multistage, and heterogeneous disease. Systemic treatment of breast cancer has changed significantly over the last decade. With a better knowledge of the pathogenesis, researchers and scientists have discovered numerous signaling pathways and synonymous therapeutic targets in breast cancer. Because of the molecular nature of breast cancer, which makes it difficult to understand, previous attempts to treat or prevent it have failed. However, recent decades have provided effective therapeutic targets for treatment. In this review, literature or information on various targeted therapy for breast cancer is discussed. English language articles were explored in numerous directory or databases like PubMed, Web of Sciences, Google Scholar, ScienceDirect, and Scopus. The important keywords used for searching databases are "Breast cancer," "Targeted therapy in breast cancer," "Therapeutic drugs in breast cancer," and "Molecular targets in breast cancer."
乳腺癌是一种多因素、多阶段且异质性的疾病。在过去十年中，乳腺癌的全身治疗发生了显著变化。随着对发病机制的深入了解，研究人员和科学家们在乳腺癌中发现了众多信号通路和相应的治疗靶点。由于乳腺癌的分子特性使其难以理解，以往治疗或预防乳腺癌的尝试均告失败。然而，近几十年来已为治疗提供了有效的治疗靶点。在本综述中，将讨论有关乳腺癌各种靶向治疗的文献或信息。通过在众多数据库或索引中检索英文文章，如PubMed、科学网、谷歌学术、ScienceDirect和Scopus。用于搜索数据库的重要关键词为“乳腺癌”、“乳腺癌的靶向治疗”、“乳腺癌的治疗药物”以及“乳腺癌的分子靶点”。
