Benabdallah Wajdi, Ben Othmane Mouna, Ouahchi Ines, Mestiri Sarra, Belkacem Oussama, Bouassida Khaireddine, Hmida Wissem, Jaidane Mehdi
Urology Department.
Department of Cytogenetic and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia.
Ann Med Surg (Lond). 2023 Apr 11;85(5):1885-1887. doi: 10.1097/MS9.0000000000000374. eCollection 2023 May.
Plasmacytoid carcinoma of the bladder is a rare histological variant of urothelial carcinoma associated with late presentation. This pattern of disease may portend an extremely poor prognosis and significant challenges for treatment with curative intent.
The authors report a case of a patient with locally advanced plasmacytoid urothelial carcinoma (PUC) of the bladder. A 71-year-old man with a history of chronic obstructive pulmonary disease presented with gross hematuria. The rectal examination revealed a fixed bladder base. A computed tomography scan showed a pedunculated lesion arising from the anterior and left lateral bladder wall and extended to the perivesical fat. The patient underwent transurethral resection of the tumor. The histologic examination revealed the presence of muscle-invasive PUC of the bladder. The decision of the multidisciplinary consultation meeting was to do palliative chemotherapy. Thus, the patient could not receive systemic chemotherapy and died 6 weeks after transurethral resection of the bladder tumor.
A plasmacytoid variant of urothelial carcinoma is a rare subtype of urothelial carcinoma that has a poor prognosis with a high mortality rate. The disease is usually diagnosed at an advanced stage. Given the rarity of plasmacytoid bladder cancer, treatment guidelines are not clear; therefore, more aggressive treatment may be required.
PUC of the bladder is characterized by high aggressiveness, an advanced stage at the time of diagnosis, and a poor prognosis.
膀胱浆细胞样癌是尿路上皮癌的一种罕见组织学变异型，与疾病晚期表现相关。这种疾病模式可能预示预后极差，且根治性治疗面临重大挑战。
作者报告一例膀胱局部晚期浆细胞样尿路上皮癌（PUC）患者。一名有慢性阻塞性肺疾病病史的71岁男性因肉眼血尿就诊。直肠指检发现膀胱底部固定。计算机断层扫描显示一个带蒂病变，起源于膀胱前壁和左侧壁，并延伸至膀胱周围脂肪。患者接受了经尿道肿瘤切除术。组织学检查显示为膀胱肌层浸润性PUC。多学科会诊会议决定进行姑息化疗。因此，患者无法接受全身化疗，在经尿道膀胱肿瘤切除术后6周死亡。
尿路上皮癌的浆细胞样变异型是尿路上皮癌的一种罕见亚型，预后差，死亡率高。该疾病通常在晚期才被诊断出来。鉴于浆细胞样膀胱癌罕见，治疗指南尚不明确；因此，可能需要更积极的治疗。
膀胱PUC具有侵袭性高、诊断时处于晚期以及预后差的特点。
