Zahlout Jaafar, Shmayyes Nour A, Zahlout Batoul, Kassab Yahya, Alshehabi Zuheir
Department of Internal Medicine.
Department of Internal Medicine, Al-Mouwasat Teaching Hospital, Damascus, Syrian Arab Republic.
Ann Med Surg (Lond). 2023 Apr 3;85(5):1852-1856. doi: 10.1097/MS9.0000000000000351. eCollection 2023 May.
The coexistence of a benign Brenner tumour and a mucinous cystadenoma is rare, and their relationship and origin are still enigmatic and challenging.
In this manuscript, the authors report a case of a 62-year-old nulliparous Syrian woman who presented with severe abdominal distension, which was followed by laparotomy and the excision of a 25×20 cm-cyst; its pathological examination confirmed a benign Brenner's tumour and mucinous cystadenoma.
Ovarian Brenner and mucinous are usually benign and can rarely grow asymptomatically to very big sizes. Herein, the authors aim to emphasize the importance of excluding malignancy by pathology examination.
Walthard cell nests undergo metaplasia to give rise to different kinds of Brenner and mucinous neoplasm formations according to their genetic alterations. This paper adds to the available literature, which is still poor, by providing evidence of the first case of this rare combination from Syria with a review of different theories of origin and differential diagnoses. More studies directed towards exploring this combination's genetic origin are needed to boost our understanding of ovarian tumours in general.
良性布伦纳瘤与黏液性囊腺瘤并存的情况罕见，它们之间的关系及起源仍不明确且具有挑战性。
在本手稿中，作者报告了一例62岁未生育的叙利亚女性病例，该患者出现严重腹胀，随后接受剖腹手术并切除了一个25×20厘米的囊肿；其病理检查证实为良性布伦纳瘤和黏液性囊腺瘤。
卵巢布伦纳瘤和黏液性肿瘤通常为良性，很少无症状生长至非常大的尺寸。在此，作者旨在强调通过病理检查排除恶性肿瘤的重要性。
瓦尔塔德细胞巢发生化生，根据其基因改变产生不同类型的布伦纳瘤和黏液性肿瘤形成。本文通过提供叙利亚首例这种罕见组合病例的证据，并回顾不同的起源理论和鉴别诊断，为目前仍很匮乏的文献增添了内容。需要开展更多旨在探索这种组合基因起源的研究，以增进我们对卵巢肿瘤总体的理解。
