Dartmouth Cancer Center and the Geisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, USA.
Dartmouth Cancer Center and the Geisel School of Medicine at Dartmouth, Department of Microbiology and Immunology, USA.
Curr Opin Immunol. 2023 Aug;83:102338. doi: 10.1016/j.coi.2023.102338. Epub 2023 May 23.
Tissue-resident memory (Trm) cells have recently emerged as essential components of the immune response to cancer. Here, we highlight new studies that demonstrate how CD8 Trm cells are ideally suited to accumulate in tumors and associated tissues, to recognize a wide range of tumor antigens (Ags), and to persist as durable memory. We discuss compelling evidence that Trm cells maintain potent recall function and serve as principal mediators of immune checkpoint blockade (ICB) therapeutic efficacy in patients. Finally, we propose that Trm and circulating memory T-cell compartments together form a formidable barrier against metastatic cancer. These studies affirm Trm cells as potent, durable, and necessary mediators of cancer immunity.
组织驻留记忆 (Trm) 细胞最近已成为癌症免疫反应的重要组成部分。在这里，我们重点介绍了一些新的研究，这些研究表明 CD8 Trm 细胞如何非常适合在肿瘤和相关组织中积累，识别广泛的肿瘤抗原 (Ags)，并作为持久的记忆细胞存在。我们讨论了令人信服的证据，表明 Trm 细胞保持强大的回忆功能，并作为免疫检查点阻断 (ICB) 治疗疗效在患者中的主要介导者。最后，我们提出 Trm 细胞和循环记忆 T 细胞共同构成了对抗转移性癌症的强大障碍。这些研究证实了 Trm 细胞作为癌症免疫的有力、持久和必要的介导者。
