Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, United States.
Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, United States.
Curr Opin Immunol. 2022 Feb;74:68-75. doi: 10.1016/j.coi.2021.10.005. Epub 2021 Nov 15.
Tissue resident memory T cells (T) are enriched in non-lymphoid tissues and represent a formidable barrier against invading pathogens and tumors. T are armed with deployment ready effector molecules which combined with their frontline location allows them to be early organizing centers of our immune defense. Despite their autonomous nature, T rely on careful collaboration with other immune and non-immune cells located within the barrier organ to exert their superior protective role. Here, we highlight recent studies focusing on cellular interactions that regulate T establishment and function. A deeper understanding of these processes is instrumental in designing new means to target T for desirable outcomes in infectious diseases, cancers and autoimmunity.
组织驻留记忆 T 细胞（T）富含于非淋巴组织中，是抵御入侵病原体和肿瘤的强大屏障。T 细胞装备有随时可用的效应分子，再加上其前线位置，使它们成为我们免疫防御的早期组织中心。尽管具有自主性，但 T 细胞依赖于与其所在屏障器官内的其他免疫和非免疫细胞的仔细协作，以发挥其卓越的保护作用。在这里，我们重点介绍了最近关注调节 T 细胞建立和功能的细胞相互作用的研究。深入了解这些过程对于设计针对传染病、癌症和自身免疫性疾病中 T 细胞的靶向治疗方法具有重要意义。
