癌症中非编码 RNA 的修饰及其治疗意义。

Modifications of noncoding RNAs in cancer and their therapeutic implications.

机构信息

Center for Reproductive Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia, China.

Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612-9497, USA.

出版信息

Cell Signal. 2023 Aug;108:110726. doi: 10.1016/j.cellsig.2023.110726. Epub 2023 May 23.

DOI:10.1016/j.cellsig.2023.110726

PMID:37230201

Abstract

In the last 50 years, over 150 various chemical modifications on RNA molecules, including mRNAs, rRNAs, tRNAs, and other noncoding RNAs (ncRNAs), have been identified and characterized. These RNA modifications regulate RNA biogenesis and biological functions and are widely involved in various physiological processes and diseases, including cancer. In recent decades, broad interest has arisen in the epigenetic modification of ncRNAs due to the increased knowledge of the critical roles of ncRNAs in cancer. In this review, we summarize the various modifications of ncRNAs and highlight their roles in cancer initiation and progression. In particular, we discuss the potential of RNA modifications as novel biomarkers and therapeutic targets in cancer.

摘要

在过去的 50 年中，已经鉴定和表征了超过 150 种对 RNA 分子（包括 mRNA、rRNA、tRNA 和其他非编码 RNA（ncRNA））的各种化学修饰。这些 RNA 修饰调节 RNA 的生物发生和生物学功能，并广泛参与各种生理过程和疾病，包括癌症。近几十年来，由于 ncRNA 在癌症中的关键作用的知识不断增加，ncRNA 的表观遗传修饰引起了广泛的兴趣。在这篇综述中，我们总结了 ncRNA 的各种修饰，并强调了它们在癌症发生和发展中的作用。特别是，我们讨论了 RNA 修饰作为癌症新型生物标志物和治疗靶点的潜力。