粉红区征（PP）征：一种用于早期胃癌的新型简单标志物。
The Pink Zone Pattern (PP) sign: A novel simple marker for early gastric cancer.
机构信息
Department of Endoscopy, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, China.
Department of Endoscopy, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, China.
出版信息
Dig Liver Dis. 2023 Aug;55(8):1100-1104. doi: 10.1016/j.dld.2023.05.003. Epub 2023 May 24.
BACKGROUND
We previously found a pink-colored change in early gastric cancer (EGC) lesions under magnifying endoscopy with narrow-band imaging (ME-NBI) and named it the "Pink Zoon Pattern" (PP) sign, which appeared independent of microvascular and microstructural changes. The aim of this study was to further investigate the characteristics of the PP sign in EGC.
METHODS
The consecutive patients with suspicious gastric lesions detected by ME-NBI and confirmed by pathology at Zhejiang Cancer Hospital between November 2020 and December 2021 were enrolled in the study. The suspicious lesions were observed and assessed by the "VS" system and the PP sign respectively.
RESULTS
We found that in the PP-positive group, 238 lesions (96.0%) were diagnosed as malignant. The overall accuracy, sensitivity, and specificity were 84.7%, 85.3%, and 81.8%. Among 164 EGC lesions diagnosed with low confidence (Grades 2, 3, and 4) using the VS system, the overall accuracy of PP to discriminate tumor from normal was 82.3%. The sensitivity and specificity were 82.7% and 81.5% respectively.
CONCLUSIONS
The PP sign could be a new simple sign for the diagnosis of EGC and as an effective supplement to VS system when using ME-NBI.
背景
我们之前在使用窄带成像放大内镜（ME-NBI）检查时发现早期胃癌（EGC）病变呈粉红色改变，并将其命名为“粉红色泽图案”（PP）征，该征独立于微血管和微结构变化。本研究旨在进一步研究 EGC 中 PP 征的特征。
方法
本研究纳入 2020 年 11 月至 2021 年 12 月在浙江省肿瘤医院接受 ME-NBI 检查且经病理证实的可疑胃病变患者。可疑病变分别采用“VS”系统和 PP 征进行观察和评估。
结果
我们发现，在 PP 阳性组中，238 个病变（96.0%）被诊断为恶性。总体准确率、敏感度和特异度分别为 84.7%、85.3%和 81.8%。在 VS 系统诊断为低可信度（2、3 和 4 级）的 164 个 EGC 病变中，PP 区分肿瘤与正常的总体准确率为 82.3%。敏感度和特异度分别为 82.7%和 81.5%。
结论
PP 征可作为诊断 EGC 的新的简单征象，并且是 ME-NBI 中 VS 系统的有效补充。
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