Van der Wiel H L, Van Gijn J
J Neurol Sci. 1986 May;73(3):311-6. doi: 10.1016/0022-510x(86)90155-3.
We prospectively studied the value of the cocaine test in the diagnosis of Horner's syndrome, by performing the test in 20 control subjects and in 20 patients with a provisional diagnosis of Horner's syndrome. Photographic testing of the darkness reflex of the pupil was used as an independent criterion of oculosympathetic dysfunction, and confirmed the diagnosis in 12 of the 20 patients. A mydriatic response to cocaine that was at least 1.0 mm less than in the unaffected eye occurred only with Horner's syndrome (7 patients). On the other hand, if the difference is smaller than 1.0 mm the chance that the patient does not have Horner's syndrome is only around 60%. There was no relationship between the magnitude of the response to cocaine and the site of the lesion in the sympathetic system.
我们通过对20名对照受试者和20名初步诊断为霍纳综合征的患者进行可卡因试验，前瞻性地研究了该试验在霍纳综合征诊断中的价值。瞳孔暗反射的摄影测试被用作眼交感神经功能障碍的独立标准，并在20名患者中的12名中证实了诊断。仅在霍纳综合征患者（7例）中出现对可卡因的散瞳反应比未受影响的眼睛至少小1.0毫米的情况。另一方面，如果差异小于1.0毫米，患者没有霍纳综合征的可能性仅约为60%。对可卡因的反应程度与交感神经系统病变部位之间没有关系。
