Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Department of Pediatric Unit of Pediatric Nephrology, Faculty of Medicine UFMG, Belo Horizonte, Minas Gerais, Brazil.
Mini Rev Med Chem. 2024;24(5):491-506. doi: 10.2174/1389557523666230523114331.
Cardiovascular Disease is the leading cause of death in adult and pediatric patients with Chronic Kidney Disease (CKD) and its pathogenesis involves the interaction of multiple pathways. As Inflammatory mechanisms play a critical role in the vascular disease of CKD pediatric patients, there are several biomarkers related to inflammation strongly associated with this comorbidity.
This review provides available evidence on the link between several biomarkers and the pathophysiology of heart disease in patients with CKD.
The data were obtained independently by the authors, who carried out a comprehensive and non-systematic search in PubMed, Cochrane, Scopus, and SciELO databases. The search terms were "Chronic Kidney Disease", "Cardiovascular Disease", "Pediatrics", "Pathophysiology", "Mineral and Bone Disorder (MBD)", "Renin Angiotensin System (RAS)", "Biomarkers", "BNP", "NTproBNP", "CK-MB", "CXCL6", "CXCL16", "Endocan-1 (ESM-1)", "FABP3", "FABP4", h-FABP", "Oncostatin- M (OSM)", "Placental Growth Factor (PlGF)" and "Troponin I".
The pathogenesis of CKD-mediated cardiovascular disease is linked to inflammatory biomarkers, which play a critical role in the initiation, maintenance, and progression of cardiovascular disease. There are several biomarkers associated with cardiovascular disease in pediatric patients, including BNP, NTproBNP, CK-MB, CXCL6, CXCL16, Endocan-1 (ESM-1), FABP3, FABP4, Oncostatin- M (OSM), Placental Growth Factor (PlGF), and Troponin I.
The pathogenesis of CKD-mediated cardiovascular disease is not completely understood, but it is linked to inflammatory biomarkers. Further studies are required to elucidate the pathophysiological and potential role of these novel biomarkers.
心血管疾病是慢性肾脏病（CKD）成人和儿科患者死亡的主要原因，其发病机制涉及多种途径的相互作用。由于炎症机制在 CKD 儿科患者的血管疾病中起着关键作用，因此有几个与炎症相关的生物标志物与这种合并症密切相关。
本综述提供了有关几种生物标志物与 CKD 患者心脏病病理生理学之间联系的现有证据。
作者独立获取数据，对 PubMed、Cochrane、Scopus 和 SciELO 数据库进行了全面和非系统性搜索。检索词为“慢性肾脏病”、“心血管疾病”、“儿科”、“病理生理学”、“矿物质和骨代谢紊乱（MBD）”、“肾素-血管紧张素系统（RAS）”、“生物标志物”、“BNP”、“NT-proBNP”、“CK-MB”、“CXCL6”、“CXCL16”、“内皮细胞特异性分子-1（ESM-1）”、“脂肪酸结合蛋白 3（FABP3）”、“脂肪酸结合蛋白 4（FABP4）”、“h-FABP”、“肿瘤坏死因子-α（OSM）”、“胎盘生长因子（PlGF）”和“肌钙蛋白 I”。
CKD 介导的心血管疾病的发病机制与炎症生物标志物有关，这些生物标志物在心血管疾病的发生、维持和进展中起着关键作用。有几种与儿科患者心血管疾病相关的生物标志物，包括 BNP、NT-proBNP、CK-MB、CXCL6、CXCL16、内皮细胞特异性分子-1（ESM-1）、脂肪酸结合蛋白 3（FABP3）、脂肪酸结合蛋白 4（FABP4）、肿瘤坏死因子-α（OSM）、胎盘生长因子（PlGF）和肌钙蛋白 I。
CKD 介导的心血管疾病的发病机制尚不完全清楚，但与炎症生物标志物有关。需要进一步研究来阐明这些新型生物标志物的病理生理学和潜在作用。
