Key Laboratory for Advanced Materials, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
Shenzhen Key Lab of Functional Polymer, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, P. R. China.
Dalton Trans. 2023 Jun 13;52(23):8051-8057. doi: 10.1039/d3dt01001e.
A ruthenium complex [Ru(phen)(phen-5-amine)-C14] (Ru-C14) with broad-spectrum antibacterial activity was designed and synthesized; positively charged Ru-C14 could target bacteria electrostatic interactions and showed high binding effectiveness to cell membranes. In addition, Ru-C14 could act as a photosensitizer. Under 465 nm light irradiation, Ru-C14 could generate O, thus disrupting the bacterial intracellular redox balance and leading to bacterial death. Ru-C14 also exhibited minimum inhibitory concentration values of 6.25 μM against and 3.125 μM against ; these values are lower than those of streptomycin and methicillin. This work combined the merits of cell membrane targeting and photodynamic therapy for antibacterial activity. The findings might open up a new avenue for effective anti-infection treatment and other medical applications.
一种具有广谱抗菌活性的钌配合物[Ru(phen)(phen-5-amine)-C14]（Ru-C14）被设计并合成；带正电荷的 Ru-C14 可以通过静电相互作用靶向细菌，并表现出对细胞膜的高结合效力。此外，Ru-C14 可以作为光动力治疗的光敏剂。在 465nm 光照射下，Ru-C14 可以产生 O2，从而破坏细菌的细胞内氧化还原平衡，导致细菌死亡。Ru-C14 对 和 的最小抑菌浓度值分别为 6.25μM 和 3.125μM，低于链霉素和甲氧西林的最小抑菌浓度值。这项工作结合了细胞膜靶向和光动力治疗的优点，具有抗菌活性。这些发现可能为有效的抗感染治疗和其他医学应用开辟了新途径。
