Trulson M E, Sampson H W
J Nutr. 1986 Jun;116(6):1109-15. doi: 10.1093/jn/116.6.1109.
Oral administration of L-tryptophan at 250 mg/(kg X d) for 3 consecutive days to rats produced enlarged hepatic sinusoids and vacuolated cells, many of which contained lipid. These changes persisted for at least 2 wk. Since the hepatic metabolism of L-tryptophan is very similar in rats and humans, these data suggest that people who self-administer large doses of L-tryptophan for the purpose of decreasing sleep latency may be inducing hepatic pathology.
连续3天以250毫克/（千克×天）的剂量给大鼠口服L-色氨酸，会导致肝血窦扩大以及细胞空泡化，其中许多细胞含有脂质。这些变化至少持续2周。由于大鼠和人类肝脏中L-色氨酸的代谢非常相似，这些数据表明，为减少入睡潜伏期而自行服用大剂量L-色氨酸的人可能会引发肝脏病变。
