Laboratory of Organic Chemistry for Drug Development and Medical Research Laboratories, Department of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minatao-ku, Tokyo 108-8641, Japan.
Laboratory of Organic Chemistry for Molecular Transformations, Department of Chemistry and the Institute of Natural Sciences, Nihon University, 3-25-40 Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan.
Chem Commun (Camb). 2023 Jun 13;59(48):7391-7394. doi: 10.1039/d3cc02071a.
Although aqueous ammonia is an inexpensive and readily available safe source of ammonia, there have been no successful studies on direct catalytic dehydrative amidations of carboxylic acids with aqueous ammonia. In this study, we report a catalytic methodology for the synthesis of primary amides through diboronic acid anhydride (DBAA)-catalyzed dehydrative condensation of carboxylic acids with aqueous ammonia as the amine substrate.
虽然氨水是一种廉价且易得的安全氨源，但目前还没有关于直接用氨水催化脱水酰胺化羧酸的成功研究。在这项研究中，我们报告了一种通过二硼酸酐 (DBAA) 催化羧酸与氨水作为胺底物的脱水缩合反应合成伯酰胺的催化方法。
