Department of Neurosurgery, College of Medicine, University of Florida, 1505 SW Archer Rd, Gainesville, FL 32608, USA.
Department of Radiology, College of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.
Curr Oncol. 2023 May 13;30(5):4990-5002. doi: 10.3390/curroncol30050377.
Focused ultrasound is a novel technique for the treatment of aggressive brain tumors that uses both mechanical and thermal mechanisms. This non-invasive technique can allow for both the thermal ablation of inoperable tumors and the delivery of chemotherapy and immunotherapy while minimizing the risk of infection and shortening the time to recovery. With recent advances, focused ultrasound has been increasingly effective for larger tumors without the need for a craniotomy and can be used with minimal surrounding soft tissue damage. Treatment efficacy is dependent on multiple variables, including blood-brain barrier permeability, patient anatomical features, and tumor-specific features. Currently, many clinical trials are currently underway for the treatment of non-neoplastic cranial pathologies and other non-cranial malignancies. In this article, we review the current state of surgical management of brain tumors using focused ultrasound.
聚焦超声是一种用于治疗侵袭性脑肿瘤的新方法，它利用机械和热机制。这种非侵入性技术可以在最小化感染风险和缩短恢复时间的同时，对无法手术的肿瘤进行热消融，并输送化疗和免疫疗法。随着最近的进展，聚焦超声对于不需要开颅手术的更大肿瘤越来越有效，并且可以最小化周围软组织损伤。治疗效果取决于多个变量，包括血脑屏障通透性、患者解剖特征和肿瘤特异性特征。目前，许多临床试验正在进行中，用于治疗非肿瘤性颅病理和其他非颅恶性肿瘤。在本文中，我们回顾了使用聚焦超声治疗脑肿瘤的手术管理现状。
