Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Int J Hyperthermia. 2021;38(1):561-575. doi: 10.1080/02656736.2021.1905189.
Histotripsy is the first noninvasive, non-ionizing, and non-thermal ablation technology guided by real-time imaging. Using focused ultrasound delivered from outside the body, histotripsy mechanically destroys tissue through cavitation, rendering the target into acellular debris. The material in the histotripsy ablation zone is absorbed by the body within 1-2 months, leaving a minimal remnant scar. Histotripsy has also been shown to stimulate an immune response and induce abscopal effects in animal models, which may have positive implications for future cancer treatment. Histotripsy has been investigated for a wide range of applications in preclinical studies, including the treatment of cancer, neurological diseases, and cardiovascular diseases. Three human clinical trials have been undertaken using histotripsy for the treatment of benign prostatic hyperplasia, liver cancer, and calcified valve stenosis. This review provides a comprehensive overview of histotripsy covering the origin, mechanism, bioeffects, parameters, instruments, and the latest results on preclinical and human studies.
声声动力是一种新型的、基于实时成像引导的、非侵入性、非电离性、非热消融技术。该技术通过体外传递聚焦超声，利用空化作用机械性地破坏组织，使靶区组织变成无细胞的碎片。声声动力消融区内的物质在 1-2 个月内被身体吸收，仅留下微小的残余疤痕。声声动力还在动物模型中显示出能刺激免疫反应和诱导远隔效应的能力，这可能对未来的癌症治疗具有积极意义。在临床前研究中，声声动力已经被广泛应用于各种治疗领域，包括癌症、神经和心血管疾病等。目前已有三项人体临床试验采用声声动力治疗良性前列腺增生、肝癌和钙化瓣膜狭窄。本文全面综述了声声动力的起源、作用机制、生物效应、参数、仪器以及临床前和人体研究的最新结果。
