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基于 MoS 纳米花和纳米金刚石协同工程的表面等离子体共振生物传感。

MoS-Nanoflower and Nanodiamond Co-Engineered Surface Plasmon Resonance for Biosensing.

机构信息

Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Jinan University, Guangzhou 510632, China.

Department of Optoelectronic Engineering, Jinan University, Guangzhou 510632, China.

出版信息

Biosensors (Basel). 2023 Apr 28;13(5):506. doi: 10.3390/bios13050506.

DOI:10.3390/bios13050506
PMID:37232867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10216570/
Abstract

Surface plasmon resonance (SPR) based sensors play an important role in the biological and medical fields, and improving the sensitivity is a goal that has always been pursued. In this paper, a sensitivity enhancement scheme jointly employing MoS nanoflower (MNF) and nanodiamond (ND) to co-engineer the plasmonic surface was proposed and demonstrated. The scheme could be easily implemented via physically depositing MNF and ND overlayers on the gold surface of an SPR chip, and the overlayer could be flexibly adjusted by controlling the deposition times, thus approaching the optimal performance. The bulk RI sensitivity was enhanced from 9682 to 12,219 nm/RIU under the optimal condition that successively deposited MNF and ND 1 and 2 times. The proposed scheme was proved in an IgG immunoassay, where the sensitivity was twice enhanced compared to the traditional bare gold surface. Characterization and simulation results revealed that the improvement arose from the enhanced sensing field and increased antibody loading via the deposited MNF and ND overlayer. At the same time, the versatile surface property of NDs allowed a specifically-functionalized sensor using the standard method compatible with a gold surface. Besides, the application for pseudorabies virus detection in serum solution was also demonstrated.

摘要

基于表面等离子体共振（SPR）的传感器在生物和医学领域中发挥着重要作用，提高其灵敏度一直是人们追求的目标。本文提出并验证了一种联合使用 MoS 纳米花（MNF）和纳米金刚石（ND）来协同设计等离子体表面的灵敏度增强方案。该方案可以通过在 SPR 芯片的金表面上物理沉积 MNF 和 ND 覆盖层来轻松实现，并且可以通过控制沉积次数来灵活调整覆盖层，从而接近最佳性能。在最佳条件下，MNF 和 ND 分别沉积 1 次和 2 次，体折射率灵敏度从 9682nm/RIU 增强到 12219nm/RIU。在 IgG 免疫分析中验证了该方案，与传统的裸金表面相比，其灵敏度提高了两倍。通过沉积的 MNF 和 ND 覆盖层，可以增强传感场并增加抗体负载，从而提高灵敏度。同时，ND 的多功能表面性质允许使用与金表面兼容的标准方法进行特定功能化传感器的制备。此外，还展示了其在血清溶液中检测伪狂犬病病毒的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/a7036aa0f1e1/biosensors-13-00506-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/42d9903115ab/biosensors-13-00506-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/4ed4463e59f7/biosensors-13-00506-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/2f2b7b91a65f/biosensors-13-00506-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/1e9ac427ea20/biosensors-13-00506-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/d5a29ba7312c/biosensors-13-00506-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/70000a2c7939/biosensors-13-00506-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/42bf70e84488/biosensors-13-00506-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/a7036aa0f1e1/biosensors-13-00506-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/42d9903115ab/biosensors-13-00506-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/4ed4463e59f7/biosensors-13-00506-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/2f2b7b91a65f/biosensors-13-00506-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/1e9ac427ea20/biosensors-13-00506-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/d5a29ba7312c/biosensors-13-00506-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/70000a2c7939/biosensors-13-00506-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/42bf70e84488/biosensors-13-00506-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bbb/10216570/a7036aa0f1e1/biosensors-13-00506-g008.jpg

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