Heck-Swain Ka-Lin, Koeppen Michael
Department of Anesthesiology and Intensive Care Medicine, University Hospital Tuebingen, 72076 Tübingen, Germany.
J Cardiovasc Dev Dis. 2023 May 14;10(5):215. doi: 10.3390/jcdd10050215.
Hypoxia-inducible factors (HIFs) play a crucial role in cellular responses to low oxygen levels during myocardial ischemia and reperfusion injury. HIF stabilizers, originally developed for treating renal anemia, may offer cardiac protection in this context. This narrative review examines the molecular mechanisms governing HIF activation and function, as well as the pathways involved in cell protection. Furthermore, we analyze the distinct cellular roles of HIFs in myocardial ischemia and reperfusion. We also explore potential therapies targeting HIFs, emphasizing their possible benefits and limitations. Finally, we discuss the challenges and opportunities in this research area, underscoring the need for continued investigation to fully realize the therapeutic potential of HIF modulation in managing this complex condition.
缺氧诱导因子（HIFs）在心肌缺血再灌注损伤期间细胞对低氧水平的反应中起关键作用。最初开发用于治疗肾性贫血的HIF稳定剂，在此背景下可能具有心脏保护作用。这篇叙述性综述探讨了HIF激活和功能的分子机制，以及细胞保护所涉及的途径。此外，我们分析了HIFs在心肌缺血和再灌注中的不同细胞作用。我们还探索了针对HIFs的潜在疗法，强调了它们可能的益处和局限性。最后，我们讨论了该研究领域的挑战和机遇，强调需要持续研究以充分实现HIF调节在管理这种复杂病症中的治疗潜力。
