Laboratory of Photobiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Laboratory of Chorioretinal Biology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Int J Mol Sci. 2024 Sep 21;25(18):10140. doi: 10.3390/ijms251810140.
Hypoxia-inducible factors (HIFs) are transcriptional factors that function as strong regulators of oxygen homeostasis and cellular metabolisms. The maintenance of cellular oxygen levels is critical as either insufficient or excessive oxygen affects development and physiologic and pathologic conditions. In the eye, retinas have a high metabolic demand for oxygen. Retinal ischemia can cause visual impairment in various sight-threating disorders including age-related macular degeneration, diabetic retinopathy, and some types of glaucoma. Therefore, understanding the potential roles of HIFs in the retina is highly important for managing disease development and progression. This review focuses on the physiologic and pathologic roles of HIFs as regulators of oxygen homeostasis and cellular metabolism in the retina, drawing on recent evidence. Our summary will promote comprehensive approaches to targeting HIFs for therapeutic purposes in retinal diseases.
缺氧诱导因子 (HIFs) 是转录因子，作为氧平衡和细胞代谢的强大调节剂发挥作用。维持细胞内氧水平至关重要，因为氧不足或过多都会影响发育以及生理和病理状况。在眼睛中，视网膜对氧的代谢需求很高。视网膜缺血可导致多种威胁视力的疾病发生视力障碍，包括年龄相关性黄斑变性、糖尿病性视网膜病变和某些类型的青光眼。因此，了解 HIF 在视网膜中的潜在作用对于管理疾病的发展和进展非常重要。本综述重点关注 HIF 作为氧平衡和视网膜细胞代谢调节剂的生理和病理作用，并参考了最近的证据。我们的总结将促进针对视网膜疾病的 HIF 治疗靶点的综合方法。
