Belachew Esmael Besufikad, Desta Adey Feleke, Deneke Dinksira Bekele, Fenta Bizunesh Dires, Alem Alemwosen Teklehaymanot, Abafogi Abdo Kedir, Lukas Fekade Yerakly, Bezabih Mesele, Sewasew Dareskedar Tsehay, Kantelhardt Eva J, Tessema Tesfaye Sisay, Howe Rawleigh
Biology Department, College of Natural and Computational Sciences, Mizan Tepi University, Addis Ababa 260, Ethiopia.
Department of Microbial, Cellular and Molecular Biology, College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa 1176, Ethiopia.
Medicines (Basel). 2023 May 4;10(5):30. doi: 10.3390/medicines10050030.
Breast cancer (BC) is the most common type of cancer in Ethiopia. The incidence of BC is also rising, but the exact figure is still poorly known. Therefore, this study was conducted to address the gap in epidemiological data on BC in southern and southwestern Ethiopia. This is a five-year (2015-2019) retrospective study. The demographic and clinicopathological data were collected from biopsy reports of different kinds of breast carcinomas in the pathology department of Jimma University Specialized Hospital and Hawassa University Specialized Referral Hospital. Histopathological grades and stages were conducted using Nottingham grading and TNM staging system, respectively. Collected data were entered and analyzed using SPSS Version-20 software. The mean age of patients at diagnosis was 42.27 (SD = 13.57) years. The pathological stage of most BC patients was stage III, and most of them had tumor sizes greater than 5 cm. Most patients had moderately differentiated tumor grade, and mastectomy was the most common type of surgery at the time of diagnosis. Invasive ductal carcinoma was the most common histological type of BC, followed by invasive lobular carcinoma. Lymph node involvement was seen in 60.5% of cases. Lymph node involvement was associated with tumor size (χ = 8.55, = 0.033) and type of surgery (χ = 39.69, < 0.001). Conclusions: This study showed that BC patients in southern and southwestern Ethiopia displayed advanced pathological stages, relatively young age at diagnosis, and predominant invasive ductal carcinoma histological patterns.
乳腺癌（BC）是埃塞俄比亚最常见的癌症类型。BC的发病率也在上升，但确切数字仍知之甚少。因此，本研究旨在填补埃塞俄比亚南部和西南部BC流行病学数据的空白。这是一项为期五年（2015 - 2019年）的回顾性研究。人口统计学和临床病理数据收集自吉姆马大学专科医院和哈瓦萨大学专科医院病理科不同类型乳腺癌的活检报告。组织病理学分级和分期分别采用诺丁汉分级和TNM分期系统。收集的数据使用SPSS 20.0软件录入并分析。患者诊断时的平均年龄为42.27岁（标准差 = 13.57）。大多数BC患者的病理分期为III期，且大多数患者肿瘤大小大于5厘米。大多数患者肿瘤分级为中度分化，诊断时乳房切除术是最常见的手术类型。浸润性导管癌是BC最常见的组织学类型，其次是浸润性小叶癌。60.5%的病例出现淋巴结受累。淋巴结受累与肿瘤大小（χ = 8.55，P = 0.033）和手术类型（χ = 39.69，P < 0.001）相关。结论：本研究表明，埃塞俄比亚南部和西南部的BC患者病理分期较晚，诊断时年龄相对较轻，且以浸润性导管癌组织学模式为主。
