Yu Jinjie, Liu Mengwen, Mijiti Xiaokaiti, Liu Haican, Wang Quan, Yin Chunjie, Anwaierjiang Aiketaguli, Xu Miao, Li Machao, Deng Lele, Xiao Hui, Zhao Xiuqin, Wan Kanglin, Li Guilian, Yuan Xiuqin
School of Public Health, University of South China, Hengyang, 421001, People's Republic of China.
State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China.
Infect Drug Resist. 2023 May 22;16:3157-3169. doi: 10.2147/IDR.S407595. eCollection 2023.
The aim of the present study was to investigate the association between vitamin D receptor () gene polymorphism and tuberculosis susceptibility, as well as the potential interaction of host genetic factors with the heterogeneity of in the population from Xinjiang, China.
From January 2019 to January 2020, we enrolled 221 tuberculosis patients as the case group and 363 staff with no clinical symptoms as the control group from four designated tuberculosis hospitals in southern Xinjiang, China. The polymorphisms of Fok I, Taq I, Apa I, Bsm I, rs3847987 and rs739837 in the were detected by sequencing. isolates were collected from the case group and identified as Beijing or non-Beijing lineage by multiplex PCR. Propensity score (PS), univariate analysis and multivariable logistic regression models were used to perform the analysis.
Our results showed that the allele and genotype frequencies of Fok I, Taq I, Apa I, Bsm I, rs3847987 and rs739837 in were not correlated with tuberculosis susceptibility or lineages of . Two out of six loci of the gene formed one haplotype block, and none of the haplotypes was found to correlate with tuberculosis susceptibility or lineages of infected.
Polymorphisms in the gene may not indicate susceptibility to tuberculosis. There was also no evidence on the interaction between the gene of host and the lineages of in the population from Xinjiang, China. Further studies are nonetheless required to prove our conclusions.
本研究旨在探讨维生素D受体（VDR）基因多态性与结核病易感性之间的关联，以及中国新疆人群中宿主遗传因素与结核分枝杆菌（MTB）异质性之间的潜在相互作用。
2019年1月至2020年1月，我们从中国新疆南部的四家指定结核病医院招募了221例结核病患者作为病例组，363名无临床症状的工作人员作为对照组。通过测序检测VDR基因中Fok I、Taq I、Apa I、Bsm I、rs3847987和rs739837的多态性。从病例组收集MTB分离株，并通过多重PCR鉴定为北京或非北京谱系。采用倾向评分（PS）、单因素分析和多变量逻辑回归模型进行分析。
我们的结果表明，VDR基因中Fok I、Taq I、Apa I、Bsm I、rs3847987和rs739837的等位基因和基因型频率与结核病易感性或MTB谱系无关。VDR基因六个位点中的两个形成一个单倍型块，未发现任何单倍型与结核病易感性或感染的MTB谱系相关。
VDR基因多态性可能不表明对结核病的易感性。在中国新疆人群中，也没有证据表明宿主的VDR基因与MTB谱系之间存在相互作用。尽管如此，仍需要进一步研究来证实我们的结论。
