Buxton Miatta A, Heydarzadeh Safa, Gronlund Carina J, Castillo-Castrejon Marisol, Godines-Enriquez Myrna Souraye, O'Neill Marie S, Vadillo-Ortega Felipe
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI 48104, USA.
Toxics. 2023 May 3;11(5):424. doi: 10.3390/toxics11050424.
High blood pressure (BP) is a risk factor for hypertensive disease during pregnancy. Exposure to multiple toxic air pollutants can affect BP in pregnancy but has been rarely studied. We evaluated trimester-specific associations between air pollution exposure and systolic (SBP) and diastolic BP (DBP). Ozone (O), sulfur dioxide (SO), carbon monoxide (CO), nitrogen dioxide (NO), and particulate matter less than 10 and 2.5 μm in aerodynamic diameter (PM, PM) in the Pregnancy Research on Inflammation, Nutrition, & City Environment: Systematic Analyses (PRINCESA) study. Multipollutant generalized linear regression models with each pollutant and O were fit. Due to nonlinear pollution/BP associations, results are presented for "below the median" or "above the median", where the beta estimate is the change in BP at a pollutant's median versus BP at the pollutant's minimum or maximum, respectively. Associations varied across trimesters and pollutants, and deleterious associations (higher blood pressure with higher pollution) were found only at pollutant values below the median: for SBP with NO in the second and third trimesters, and PM during the third trimester, and for DBP, PM and NO in the second and third trimesters. Findings suggest that minimizing prenatal exposure to air pollution may reduce the risks of changes in BP.
高血压是孕期发生高血压疾病的一个风险因素。接触多种有毒空气污染物会影响孕期血压，但这方面的研究很少。我们评估了空气污染暴露与收缩压（SBP）和舒张压（DBP）在孕期各阶段的特定关联。在“孕期炎症、营养与城市环境研究：系统分析”（PRINCESA）中研究了臭氧（O₃）、二氧化硫（SO₂）、一氧化碳（CO）、二氧化氮（NO₂）以及空气动力学直径小于10和2.5微米的颗粒物（PM₁₀、PM₂.₅）。采用包含每种污染物和臭氧的多污染物广义线性回归模型进行拟合。由于污染与血压之间存在非线性关联，结果按照“低于中位数”或“高于中位数”呈现，其中β估计值分别是污染物处于中位数时血压相对于处于最小值或最大值时血压的变化。关联在不同孕期和污染物之间有所不同，并且仅在污染物值低于中位数时发现了有害关联（污染程度越高，血压越高）：对于收缩压，在孕中期和孕晚期与二氧化氮相关，在孕晚期与PM₁₀相关；对于舒张压，在孕中期和孕晚期与PM₂.₅和二氧化氮相关。研究结果表明，尽量减少孕期空气污染暴露可能会降低血压变化的风险。
