Tauchi K, Kawanishi H, Takeshima T
J Toxicol Sci. 1986 May;11(2):125-34. doi: 10.2131/jts.11.125.
To investigate the teratogenicity of 4-bromophenyl chloromethyl sulfone (BCS), doses of 0, 5, 35 and 245 mg/kg/day of the test substance were administered by oral gavage to Wistar-Imamichi rats from days 6 to 15 of gestation. The results were as follows: The treated dams did not exhibit any toxic symptoms or mortality attributable to the test substance. The following changes were noted in the treated dams: dose-dependent reduction of body weight gain and food intake in 35 and 245 mg/kg groups, and decreased water intake, reduced brain and thymus weights and increased relative weights of liver and kidney in the 245 mg/kg group. Fetal toxicity, increase of mortality and body weight depression, caused by the test substance was not observed. External, skeletal and visceral examination of the fetuses did not reveal any abnormalities ascribed to the test substance. With regard to ossification, the incidence of fetuses with delayed ossification of the 2nd and 5th sternebrae was significantly higher than in the control group. In summary, dams given BCS in doses of 35 mg/kg and 245 mg/kg displayed toxic manifestations. Fetuses showed slightly delayed ossification. However, the test substance was concluded to be free of any lethal or teratogenic effects.
为研究4-溴苯基氯甲基砜（BCS）的致畸性，在妊娠第6至15天，通过灌胃法将0、5、35和245 mg/kg/天剂量的受试物给予Wistar-Imamichi大鼠。结果如下：受试母鼠未表现出任何由受试物引起的毒性症状或死亡。在受试母鼠中观察到以下变化：35和245 mg/kg组体重增加和食物摄入量呈剂量依赖性减少，245 mg/kg组水摄入量减少、脑和胸腺重量减轻以及肝脏和肾脏相对重量增加。未观察到受试物引起的胎儿毒性、死亡率增加和体重降低。对胎儿进行的外观、骨骼和内脏检查未发现任何归因于受试物的异常。关于骨化，第2和第5胸骨节骨化延迟的胎儿发生率显著高于对照组。总之，给予35 mg/kg和245 mg/kg剂量BCS的母鼠表现出毒性表现。胎儿显示出轻微的骨化延迟。然而，结论是受试物没有任何致死或致畸作用。
