Minocha A, Herold D A, Barth J T, Gideon D A, Spyker D A
J Toxicol Clin Toxicol. 1986;24(3):225-34. doi: 10.3109/15563658608990460.
Activated charcoal has been recommended for use in poisonings by ethanol, other toxic alcohols and glycols, but it has been avoided with therapeutic use of oral ethanol. Six healthy young adults drank a dose of ethanol designed to give a peak concentration of 125 mg/dl on two different days after overnight fasting. Each individual drank the same dose on both occasions; but on one of these days, the subjects drank an aqueous slurry of 60 g of superactive charcoal prior to ethanol ingestion. We compared the pharmacokinetic profile of ethanol with and without activated charcoal treatment. The fraction of ethanol absorbed was similar on both protocols. The mean peak ethanol concentration after pretreatment with activated charcoal was 8% greater than ethanol alone (p = 0.08). Thus oral activated charcoal does not significantly impair ethanol absorption and can be used in patients requiring oral ethanol. Our results do not support the use of activated charcoal in overdose of ethanol alone. Extending our results to poisonings by other toxic alcohols and glycols, the use of activated charcoal to reduce their absorption deserves evaluation.
活性炭已被推荐用于乙醇、其他有毒醇类和二醇类中毒，但在口服乙醇进行治疗时应避免使用。六名健康的年轻成年人在禁食过夜后的两天分别饮用了一定剂量的乙醇，旨在使血药浓度峰值达到125mg/dl。每次每个人饮用相同剂量；但在其中一天，受试者在摄入乙醇前饮用了60g超级活性炭的水悬液。我们比较了有无活性炭治疗时乙醇的药代动力学特征。两种方案中乙醇的吸收分数相似。活性炭预处理后的乙醇平均血药浓度峰值比单独使用乙醇时高8%（p = 0.08）。因此，口服活性炭不会显著损害乙醇吸收，可用于需要口服乙醇的患者。我们的结果不支持单独使用活性炭治疗乙醇过量。将我们的结果推广到其他有毒醇类和二醇类中毒，使用活性炭减少其吸收值得评估。
