Holzgraefe M, Poser W, Kijewski H, Beuche W
J Toxicol Clin Toxicol. 1986;24(3):235-44. doi: 10.3109/15563658608990461.
To our knowledge, this is the first case report of a multiple, low dosage ingestion of manganese. A 66-year-old male patient is presented, who ingested 125 ml of a 8% solution of potassium permanganate (10 g) within 4 weeks. As early as 2 weeks after the beginning of poisoning, psychological alterations were noted. Neurological examination revealed disturbances of many subsystems of the CNS. Visually evoked potentials showed prolongation of the P2-latency, not reported in earlier publications. Levels for manganese were elevated in peripheral blood as well as in hair samples. Treatment with calcium trisodium pentetate decreased serum levels and increased urine excretion of manganese. Nine months after poisoning, the first signs of progressive Parkinson disease became evident. The time-course of neurological symptoms seems to depend on a critical dose of manganese.
据我们所知，这是首例多次低剂量摄入锰的病例报告。本文介绍了一名66岁男性患者，其在4周内摄入了125毫升8%的高锰酸钾溶液（10克）。早在中毒开始2周后，就发现了心理改变。神经学检查显示中枢神经系统多个子系统出现紊乱。视觉诱发电位显示P2潜伏期延长，这在早期出版物中未见报道。外周血和头发样本中的锰水平升高。用喷替酸钙钠治疗可降低血清水平并增加尿锰排泄。中毒9个月后，帕金森病进展的最初迹象变得明显。神经症状的病程似乎取决于锰的临界剂量。
