Edmunds M, Sheehan T M, Van't Hoff W
J Toxicol Clin Toxicol. 1986;24(3):245-55. doi: 10.3109/15563658608990462.
The successful supportive management of an acute strychnine ingestion is described; clinical and biochemical findings are reported. A gas chromatographic assay for serum strychnine has been applied to the analysis of 19 serial blood samples. Four hours post ingestion, the serum strychnine concentration was 1.6 mg/L. This declined with T 1/2 [corrected] of 10 hours over a period of 50 hours. First order kinetics are indicated. Management of strychnine poisoning in general is discussed in the light of this case and the limited knowledge of the pharmacokinetics of the alkaloid in man.
本文描述了急性士的宁中毒的成功支持性治疗，并报告了临床和生化检查结果。应用气相色谱法检测血清士的宁，对19份连续血样进行了分析。摄入后4小时，血清士的宁浓度为1.6mg/L。在50小时内，其浓度以10小时的半衰期下降，提示为一级动力学。结合该病例及对人体生物碱药代动力学的有限认识，对士的宁中毒的一般治疗进行了讨论。
