Division of Molecular & Clinical Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK.
Tumour Virus Res. 2023 Dec;16:200263. doi: 10.1016/j.tvr.2023.200263. Epub 2023 Jun 7.
The International Papillomavirus Conference was held in Washington DC in April 2023 and encompassed wide ranging basic, clinical and public health research relating to animal and human papillomaviruses. This editorial is a personal reflection, it does not attempt to be comprehensive and reports on some key aspects centred on the prospects for immune interventions in prevention and treatment of HPV infections and early precancers with a focus on cervical neoplasia. There is optimism for the future impact of immunotherapy in treating early HPV associated disease. This will depend on developing an appropriate design of vaccines and delivery vehicles which then need to be properly tested in clinical trials that are able to measure a useful clinical endpoint. Thereafter vaccines (prophylactic or therapeutic) still need global access and sufficient uptake to deliver impact and a key and necessary driver is education.
2023 年 4 月，国际乳头瘤病毒会议在华盛顿特区举行，会议涵盖了广泛的与动物和人类乳头瘤病毒相关的基础、临床和公共卫生研究。这篇社论是个人反思，它并非试图面面俱到，而是集中报告了一些关键方面，主要是关于免疫干预在预防和治疗 HPV 感染和早期癌前病变方面的前景，重点是宫颈癌。免疫疗法在治疗早期 HPV 相关疾病方面具有未来的积极影响。这将取决于开发适当的疫苗设计和输送载体，然后需要在临床试验中进行适当的测试，以测量有用的临床终点。此后，疫苗（预防性或治疗性）仍需要全球普及和足够的使用率，以产生影响，而教育是一个关键且必要的推动因素。
