Extract and Allergen Evaluation Lab., Egyptian Drug Authority (EDA), Giza, Egypt.
Microbiology and Immunology Department, Faculty of Pharmacy, Sinai University, Egypt.
Microb Pathog. 2022 Oct;171:105747. doi: 10.1016/j.micpath.2022.105747. Epub 2022 Sep 5.
Human papillomavirus (HPV) is the most prevalent sexually transmitted disease in the world. Even though preventive vaccines against HPV are effective, the effective treatment of HPV infections is much less satisfactory due to multi-drug resistance and secondary adverse effects. Nanotechnology was employed for the delivery of anti-cancer drugs to increase the effectiveness of the treatment and minimize the side effects. Nanodelivery of both preventive and therapeutic HPV vaccines has also been studied to boost vaccine efficacy. Overall, such developments suggest that the nanoparticle-based vaccine might emerge as the most cost-effective way to prevent and treat HPV cancer, assisted or combined with another nanotechnology-based therapy. This review focuses on the current knowledge on pathogenesis and vaccines against HPV, highlighting the current value and perspective regarding the widespread diffusion of HPV vaccines-based nanomaterials. The ongoing advancements in the design of vaccines-based nanomaterials are expanding their therapeutic roles against HPV.
人乳头瘤病毒（HPV）是世界上最普遍的性传播疾病。尽管 HPV 预防性疫苗是有效的，但由于多药耐药性和继发性不良反应，HPV 感染的有效治疗方法则不尽如人意。纳米技术被用于抗癌药物的递送来提高治疗效果并最小化副作用。预防性和治疗性 HPV 疫苗的纳米递药也已被研究以提高疫苗的功效。总的来说，这些进展表明，基于纳米颗粒的疫苗可能成为预防和治疗 HPV 癌症最具成本效益的方法，辅助或结合另一种基于纳米技术的治疗方法。这篇综述重点介绍了 HPV 的发病机制和疫苗的现有知识，强调了 HPV 疫苗相关纳米材料广泛传播的现有价值和前景。疫苗相关纳米材料设计的不断进步正在扩大其针对 HPV 的治疗作用。
