School of Chinese Herbal Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
School of Chinese Herbal Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Fitoterapia. 2023 Sep;169:105548. doi: 10.1016/j.fitote.2023.105548. Epub 2023 May 24.
The extract of the whole plant of Carpesium abrotanoides L. yielded five new sesquiterpenes including four eudesmanes (1-4) and one eremophilane (5). The new compounds were characterized by spectroscopic analysis especially 1D and 2D NMR spectroscopy and HRESIMS data. Structurally, both compounds 1 and 2 were sesquiterpene epoxides and 2 owned an epoxy group at C-4/C-15 position to form a spiro skeleton. Compounds 4 and 5 were two sesquiterpenes without lactones and 5 possessed a carboxy group in the molecule. Additionally, all the isolated compounds were preliminarily evaluated for the inhibitory activity against SARS-CoV-2 main protease. As a result, compound 2 showed moderate activity with an IC value of 18.79 μM, while other compounds were devoid of noticeable activity (IC > 50 μM).
莶草全草提取物中分离得到五个新的倍半萜类化合物，包括四个桉烷型倍半萜（1-4）和一个埃里莫芬烷型倍半萜（5）。这些新化合物通过光谱分析，特别是 1D 和 2D NMR 光谱和 HRESIMS 数据进行了表征。结构上，化合物 1 和 2 均为倍半萜环氧化物，2 在 C-4/C-15 位具有环氧基，形成螺环骨架。化合物 4 和 5 是两个没有内酯的倍半萜类化合物，5 分子中含有羧基。此外，对所有分离得到的化合物进行了抗 SARS-CoV-2 主要蛋白酶抑制活性的初步评价。结果表明，化合物 2 表现出中等的活性，IC 值为 18.79 μM，而其他化合物则没有明显的活性（IC > 50 μM）。
