来自糙苏的新半日花烷型倍半萜和含马来酰亚胺的化合物
New eremophilane-type sesquiterpenes and maleimide-bearing compounds from Carpesium abrotanoides L.
机构信息
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China; Institute for Insect Biotechnology, Justus-Liebig-University of Giessen, 35392 Giessen, Germany.
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China.
出版信息
Fitoterapia. 2019 Oct;138:104294. doi: 10.1016/j.fitote.2019.104294. Epub 2019 Aug 6.
Two new eremophilane-type sesquiterpenes, carperemophilanes A and B (1-2), three new maleimide-bearing compounds, carpesiumaleimides A-C (3-5), along with a known sesquiterpene, carabrol (6), were isolated from the ethanol extract of Carpesium abrotanoides L. Their structures were elucidated by analysis of their NMR and MS data as well as by comparison with the literature. The absolute configuration of carperemophilane A (1) was determined by single-crystal X-ray diffraction analysis. All isolated compounds (1-6) were evaluated in vitro for cytotoxicity against two human cancer cell lines MDA-MB-231 and HGC-27 using the MTT method. Compounds 1, 2 and 6 showed cytotoxic activities with IC values ranging from 7.45 to 37.35 μM.
从飞廉属植物 Carpesium abrotanoides L 的乙醇提取物中分离得到了两种新的半日花烷型倍半萜类化合物，即 carperemophilanes A 和 B（1-2），三种新的含马来酰亚胺化合物，即 carpesiumaleimides A-C（3-5），以及一种已知的倍半萜类化合物 carabrol（6）。通过分析它们的 NMR 和 MS 数据以及与文献的比较，确定了它们的结构。通过单晶 X 射线衍射分析确定了 carperemophilane A（1）的绝对构型。采用 MTT 法评价了所有分离得到的化合物（1-6）对两种人癌细胞系 MDA-MB-231 和 HGC-27 的体外细胞毒性。化合物 1、2 和 6 表现出细胞毒性，IC 值范围为 7.45-37.35μM。
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