转录因子介导的干细胞命运编程。
Transcription factor-mediated programming of stem cell fate.
机构信息
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China.
Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing 100191, China.
出版信息
Trends Cell Biol. 2023 Aug;33(8):621-624. doi: 10.1016/j.tcb.2023.05.004. Epub 2023 May 24.
Direct activation of transcription factors (TFs) in human pluripotent stem cells (hPSCs) allows more rapid and efficient conversion of cell fates compared with classical approaches. Here, we summarize recent TF screening studies and established forward programming methods for different cell types, and highlight their current limitations and future perspectives.
与传统方法相比，直接激活人多能干细胞（hPSCs）中的转录因子（TFs）可以更快速、有效地改变细胞命运。在这里，我们总结了最近的 TF 筛选研究和不同细胞类型的已建立的正向编程方法，并强调了它们目前的局限性和未来的展望。
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