Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-Ku, Yokohama, Kanagawa, 236-0004, Japan.
Department of Radiation Oncology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Radiat Oncol. 2023 May 26;18(1):90. doi: 10.1186/s13014-023-02282-9.
The incidence of multicentric oral cancer is increasing. However, treatment encounters difficulty if each tumor needs to be treated simultaneously. The objective of this clinical case report is to highlight the effect of concurrent chemoradiotherapy with retrograde superselective intra-arterial infusion combined with systemic administration of cetuximab on synchronous multifocal oral squamous cell carcinomas.
A 70-year-old man presented to the hospital with multiple tumors and oral pain. Three independent tumors were found in the right dorsal tongue, left edge of the tongue, and left lower lip. Based on the characteristic appearance of the lesions and further evaluation, clinical diagnoses of right tongue cancer "T3", left tongue cancer "T2" and lower left lip cancer "T1", N2cM0 were made. Treatment was initiated with systemic administration of cetuximab, followed by intra-arterial chemoradiotherapy. Treatment results were complete response on all three local lesions, and left neck dissection was performed following the initial treatment. The patient showed no evidence of recurrence during the 4 years follow-up period.
This novel combination treatment seems to be a promising strategy for patients with synchronous multifocal oral squamous cell carcinoma.
多中心口腔癌的发病率正在增加。然而，如果需要同时治疗每个肿瘤，治疗就会遇到困难。本临床病例报告的目的是强调顺行超选择性动脉内灌注联合全身西妥昔单抗与同期多灶性口腔鳞状细胞癌的同期放化疗的效果。
一名 70 岁男性因多处肿瘤和口腔疼痛到医院就诊。在右侧舌背、左侧舌缘和左下唇发现了三个独立的肿瘤。根据病变的特征性表现和进一步评估，临床诊断为右侧舌癌“T3”、左侧舌癌“T2”和左下唇癌“T1”、N2cM0。治疗采用西妥昔单抗全身给药，然后进行动脉内放化疗。所有三个局部病变均完全缓解，初始治疗后行左颈清扫术。在 4 年的随访期间，患者无复发迹象。
这种新的联合治疗方法似乎是治疗同期多灶性口腔鳞状细胞癌患者的一种有前途的策略。
