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Infusion reactions to the chimeric EGFR inhibitor cetuximab--change to the fully human anti-EGFR monoclonal antibody panitumumab is safe.嵌合型表皮生长因子受体（EGFR）抑制剂西妥昔单抗的输注反应——改用全人源抗EGFR单克隆抗体帕尼单抗是安全的。
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本文引用的文献

1
Cetuximab, paclitaxel, carboplatin, and radiation for head and neck cancer: a toxicity analysis.西妥昔单抗、紫杉醇、卡铂联合放疗治疗头颈部肿瘤：毒性分析。
Am J Clin Oncol. 2010 Apr;33(2):144-7. doi: 10.1097/COC.0b013e3181979093.
2
Emerging profile of cetuximab in non-small cell lung cancer.西妥昔单抗在非小细胞肺癌中的新作用。
Lung Cancer. 2010 Jun;68(3):332-7. doi: 10.1016/j.lungcan.2009.07.012. Epub 2009 Sep 26.
3
Radiochemotherapy with cetuximab, cisplatin, and amifostine for locally advanced head and neck cancer: a feasibility study.局部晚期头颈部癌症的西妥昔单抗、顺铂和氨磷汀放化疗：一项可行性研究。
Int J Radiat Oncol Biol Phys. 2010 May 1;77(1):9-15. doi: 10.1016/j.ijrobp.2009.04.060. Epub 2009 Sep 8.
4
Anti-epidermal growth factor receptor monoclonal antibodies in cancer therapy.癌症治疗中的抗表皮生长因子受体单克隆抗体
Clin Exp Immunol. 2009 Oct;158(1):1-9. doi: 10.1111/j.1365-2249.2009.03992.x.
5
Prospective cost-effectiveness analysis of cetuximab in metastatic colorectal cancer: evaluation of National Cancer Institute of Canada Clinical Trials Group CO.17 trial.西妥昔单抗用于转移性结直肠癌的前瞻性成本效益分析：加拿大国立癌症研究所临床试验组CO.17试验评估
J Natl Cancer Inst. 2009 Sep 2;101(17):1182-92. doi: 10.1093/jnci/djp232. Epub 2009 Aug 7.
6
How much is life worth: cetuximab, non-small cell lung cancer, and the $440 billion question.生命价值几何：西妥昔单抗、非小细胞肺癌与那4400亿美元的问题
J Natl Cancer Inst. 2009 Aug 5;101(15):1044-8. doi: 10.1093/jnci/djp177. Epub 2009 Jun 29.
7
An economic evaluation of cetuximab combined with radiotherapy for patients with locally advanced head and neck cancer in Belgium, France, Italy, Switzerland, and the United Kingdom.西妥昔单抗联合放疗用于比利时、法国、意大利、瑞士及英国局部晚期头颈癌患者的经济学评估
Value Health. 2008 Sep-Oct;11(5):791-9. doi: 10.1111/j.1524-4733.2007.00302.x. Epub 2008 Jan 11.
8
Cetuximab: a review of its use in squamous cell carcinoma of the head and neck and metastatic colorectal cancer.西妥昔单抗：头颈部鳞状细胞癌及转移性结直肠癌应用综述
Drugs. 2007;67(17):2585-607. doi: 10.2165/00003495-200767170-00008.
9
Tumor growth inhibition with cetuximab and chemotherapy in non-small cell lung cancer xenografts expressing wild-type and mutated epidermal growth factor receptor.西妥昔单抗联合化疗对表达野生型和突变型表皮生长因子受体的非小细胞肺癌异种移植瘤的肿瘤生长抑制作用
Clin Cancer Res. 2007 Mar 1;13(5):1540-51. doi: 10.1158/1078-0432.CCR-06-1887.
10
Cetuximab: an epidermal growth factor receptor monoclonal antibody for the treatment of colorectal cancer.西妥昔单抗：一种用于治疗结直肠癌的表皮生长因子受体单克隆抗体。
Clin Ther. 2005 Jun;27(6):684-94. doi: 10.1016/j.clinthera.2005.06.003.

西妥昔单抗（爱必妥）。

Cetuximab (erbitux).

机构信息

Department of Radiologyand, University of Michigan Health System, Ann Arbor, USA.

出版信息

AJNR Am J Neuroradiol. 2010 Apr;31(4):626-7. doi: 10.3174/ajnr.A2054. Epub 2010 Feb 18.

DOI:10.3174/ajnr.A2054
PMID:20167650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7964212/
Abstract

Cetuximab, a recombinant chimeric monoclonal antibody, has been successfully used in the treatment of the head and neck and colorectal cancers. We present a review of its mechanism of action, indications, side effects and economic issues, accompanied by a clinical example from our institution.

摘要

西妥昔单抗是一种重组嵌合单克隆抗体，已成功用于头颈部和结直肠癌的治疗。我们对其作用机制、适应证、副作用和经济问题进行了综述，并结合我院的 1 例临床病例进行了介绍。