Xue Xiaochen, Liu Zhixu, Wei Hongpu, Wang Xudong
Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
National Clinical Research Center for Oral Disease, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, China.
Bioengineering (Basel). 2023 May 16;10(5):595. doi: 10.3390/bioengineering10050595.
Hemifacial microsomia (HFM) is the second most common congenital craniofacial disease and has a wide spectrum of symptoms. The classic diagnostic criterion for hemifacial microsomia is the OMENS system, which was later refined to the OMENS+ system to include more anomalies. We analyzed the data of 103 HFM patients with magnetic resonance imaging (MRI) for temporomandibular joint (TMJ) discs. The TMJ disc classification was defined into four types: D0 for normal disc size and shape; D1 for disc malformation with adequate length to cover the (reconstructed) condyle; D2 for disc malformation with inadequate length to cover the (reconstructed) condyle; and D3 for no obvious presence of a disc. Additionally, this disc classification was positively correlated with the mandible classification (correlation coefficient: 0.614, < 0.01), ear classification (correlation coefficient: 0.242, < 0.05), soft tissue classification (correlation coefficient: 0.291, < 0.01), and facial cleft classification (correlation coefficient: 0.320, < 0.01). In this study, an OMENS+D diagnostic criterion is proposed, confirming the conjecture that the development of the mandibular ramus, ear, soft tissue, and TMJ disc, as homologous and adjacent tissues, is affected to a similar degree in HFM patients.
半侧颜面短小畸形（HFM）是第二常见的先天性颅面疾病，症状表现多样。半侧颜面短小畸形的经典诊断标准是OMENS系统，该系统后来 refined 为OMENS+系统以纳入更多异常情况。我们分析了103例HFM患者颞下颌关节（TMJ）盘的磁共振成像（MRI）数据。TMJ盘分类定义为四种类型：D0为盘大小和形状正常；D1为盘畸形但长度足以覆盖（重建的）髁突；D2为盘畸形且长度不足以覆盖（重建的）髁突；D3为未明显见盘。此外，这种盘分类与下颌骨分类（相关系数：0.614，<0.01）、耳部分类（相关系数：0.242，<0.05）、软组织分类（相关系数：0.291，<0.01）和面部裂隙分类（相关系数：0.320，<0.01）呈正相关。本研究提出了OMENS+D诊断标准，证实了如下推测：在HFM患者中，下颌升支、耳、软组织和TMJ盘作为同源且相邻的组织，其发育受到的影响程度相似。 （注：原文中“refined”此处暂未准确翻译出合适中文，可根据上下文进一步优化表述。）
