Jung Un Ju
Department of Food Science and Nutrition, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 48513, Republic of Korea.
Antioxidants (Basel). 2023 May 8;12(5):1063. doi: 10.3390/antiox12051063.
Sarcopenic obesity, which refers to concurrent sarcopenia and obesity, is characterized by decreased muscle mass, strength, and performance along with abnormally excessive fat mass. Sarcopenic obesity has received considerable attention as a major health threat in older people. However, it has recently become a health problem in the general population. Sarcopenic obesity is a major risk factor for metabolic syndrome and other complications such as osteoarthritis, osteoporosis, liver disease, lung disease, renal disease, mental disease and functional disability. The pathogenesis of sarcopenic obesity is multifactorial and complicated, and it is caused by insulin resistance, inflammation, hormonal changes, decreased physical activity, poor diet and aging. Oxidative stress is a core mechanism underlying sarcopenic obesity. Some evidence indicates a protective role of antioxidant flavonoids in sarcopenic obesity, although the precise mechanisms remain unclear. This review summarizes the general characteristics and pathophysiology of sarcopenic obesity and focuses on the role of oxidative stress in sarcopenic obesity. The potential benefits of flavonoids in sarcopenic obesity have also been discussed.
肌少症性肥胖是指肌肉减少症和肥胖症同时存在，其特征是肌肉量、力量和功能下降，同时伴有异常过多的脂肪量。肌少症性肥胖作为老年人的主要健康威胁已受到广泛关注。然而，它最近已成为普通人群中的一个健康问题。肌少症性肥胖是代谢综合征和其他并发症（如骨关节炎、骨质疏松症、肝病、肺病、肾病、精神疾病和功能障碍）的主要危险因素。肌少症性肥胖的发病机制是多因素且复杂的，它由胰岛素抵抗、炎症、激素变化、身体活动减少、不良饮食和衰老引起。氧化应激是肌少症性肥胖的核心机制。一些证据表明抗氧化黄酮类化合物在肌少症性肥胖中具有保护作用，尽管确切机制尚不清楚。本综述总结了肌少症性肥胖的一般特征和病理生理学，并重点关注氧化应激在肌少症性肥胖中的作用。还讨论了黄酮类化合物在肌少症性肥胖中的潜在益处。
