Gallinat Alex, Vilahur Gemma, Padro Teresa, Badimon Lina
Cardiovascular Program-ICCC, IR-Hospital Santa Creu i Sant Pau, IIB-Sant Pau, IIBSANTPAU, 08041 Barcelona, Spain.
Centro de Investigación Biomédica en Red Cardiovascular (CIBER-CV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Antioxidants (Basel). 2023 May 13;12(5):1096. doi: 10.3390/antiox12051096.
Fermented beverages, such as wine and beer, are rich in polyphenols that have been shown to have protective effects against oxidative stress. Oxidative stress plays a central role in the pathogenesis and progression of cardiovascular disease. However, the potential benefits of fermented beverages on cardiovascular health need to be fully investigated at a molecular level. In this study, we aimed at analyzing the effects of beer consumption in modulating the transcriptomic response of the heart to an oxidative stress challenge induced by myocardial ischemia (MI) in the presence of hypercholesterolemia in a pre-clinical swine model. Previous studies have shown that the same intervention induces organ protective benefits. We report a dose-dependent up-regulation of electron transport chain members and the down-regulation of spliceosome-associated genes linked to beer consumption. Additionally, low-dose beer consumption resulted in a down-regulation of genes associated with the immune response, that was not shown for moderate-dose beer consumption. These findings, observed in animals having demonstrated beneficial effects at the organ-level, indicate that the antioxidants in beer differentially affect the myocardial transcriptome in a dose-dependent manner.
发酵饮料，如葡萄酒和啤酒，富含多酚，已证明这些多酚对氧化应激具有保护作用。氧化应激在心血管疾病的发病机制和进展中起着核心作用。然而，发酵饮料对心血管健康的潜在益处需要在分子水平上进行充分研究。在本研究中，我们旨在分析在临床前猪模型中，在存在高胆固醇血症的情况下，饮用啤酒对心脏转录组对心肌缺血（MI）诱导的氧化应激挑战的反应的调节作用。先前的研究表明，相同的干预措施可诱导器官保护益处。我们报告了与饮用啤酒相关的电子传递链成员的剂量依赖性上调以及剪接体相关基因的下调。此外，低剂量饮用啤酒导致与免疫反应相关的基因下调，而中等剂量饮用啤酒则未显示出这种情况。在器官水平已证明具有有益作用的动物中观察到的这些发现表明，啤酒中的抗氧化剂以剂量依赖的方式差异性地影响心肌转录组。
