Department of Ophthalmology, School of Medicine, Saint Louis University, St. Louis, MO 63104, USA.
Departments of Ophthalmology and Biochemistry & Molecular Biology, School of Medicine, Saint Louis University, St. Louis, MO 63104, USA.
Biomolecules. 2023 May 13;13(5):832. doi: 10.3390/biom13050832.
Age-related macular degeneration (AMD) is a progressive degenerative disease of the central retina and the leading cause of severe loss of central vision in people over age 50. Patients gradually lose central visual acuity, compromising their ability to read, write, drive, and recognize faces, all of which greatly impact daily life activities. Quality of life is significantly affected in these patients, and there are worse levels of depression as a result. AMD is a complex, multifactorial disease in which age and genetics, as well as environmental factors, all play a role in its development and progression. The mechanism by which these risk factors interact and converge towards AMD are not fully understood, and therefore, drug discovery is challenging, with no successful therapeutic attempt to prevent the development of this disease. In this review, we describe the pathophysiology of AMD and review the role of complement, which is a major risk factor in the development of AMD.
年龄相关性黄斑变性（AMD）是一种进行性的中心视网膜退行性疾病，是 50 岁以上人群中心视力严重丧失的主要原因。患者逐渐丧失中心视力，从而影响他们的阅读、书写、驾驶和识别人脸的能力，所有这些都极大地影响了日常生活活动。这些患者的生活质量受到显著影响，结果是抑郁程度更严重。AMD 是一种复杂的、多因素的疾病，其中年龄、遗传以及环境因素都在其发展和进展中起作用。这些危险因素相互作用并汇聚到 AMD 的机制尚不完全清楚，因此药物发现具有挑战性，尚无成功的治疗尝试来预防这种疾病的发展。在这篇综述中，我们描述了 AMD 的病理生理学，并回顾了补体在 AMD 发展中的主要危险因素的作用。
