National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China.
Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.
Biomolecules. 2023 May 15;13(5):838. doi: 10.3390/biom13050838.
Calcitonin gene-related peptide (CGRP) has 37 amino acids. Initially, CGRP had vasodilatory and nociceptive effects. As research progressed, evidence revealed that the peripheral nervous system is closely associated with bone metabolism, osteogenesis, and bone remodeling. Thus, CGRP is the bridge between the nervous system and the skeletal muscle system. CGRP can promote osteogenesis, inhibit bone resorption, promote vascular growth, and regulate the immune microenvironment. The G protein-coupled pathway is vital for its effects, while MAPK, Hippo, NF-κB, and other pathways have signal crosstalk, affecting cell proliferation and differentiation. The current review provides a detailed description of the bone repair effects of CGRP, subjected to several therapeutic studies, such as drug injection, gene editing, and novel bone repair materials.
降钙素基因相关肽（CGRP）有 37 个氨基酸。最初，CGRP 具有血管舒张和痛觉作用。随着研究的进展，有证据表明外周神经系统与骨代谢、成骨和骨重塑密切相关。因此，CGRP 是神经系统和骨骼肌系统之间的桥梁。CGRP 可促进成骨、抑制骨吸收、促进血管生长和调节免疫微环境。G 蛋白偶联途径对其作用至关重要，而 MAPK、Hippo、NF-κB 等途径具有信号串扰，影响细胞增殖和分化。本综述详细描述了 CGRP 的骨修复作用，并进行了多次治疗研究，如药物注射、基因编辑和新型骨修复材料。
