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髋部骨折患者术前和术后运动对 Mobility、止血平衡及预后生物标志物的有效性:一项随机对照试验的研究方案

Pre- and Postoperative Exercise Effectiveness in Mobility, Hemostatic Balance, and Prognostic Biomarkers in Hip Fracture Patients: A Study Protocol for a Randomized Controlled Trial.

作者信息

Skouras Apostolos Z, Antonakis-Karamintzas Dimitrios, Tsolakis Charilaos, Tsantes Argirios E, Kourlaba Georgia, Zafeiris Ioannis, Soucacos Fotini, Papagiannis Georgios, Triantafyllou Athanasios, Houhoula Dimitra, Savvidou Olga, Koulouvaris Panagiotis

机构信息

1st Department of Orthopaedic Surgery, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.

Sports Performance Laboratory, School of Physical Education & Sports Science, National and Kapodistrian University of Athens, 17237 Athens, Greece.

出版信息

Biomedicines. 2023 Apr 24;11(5):1263. doi: 10.3390/biomedicines11051263.

DOI:10.3390/biomedicines11051263
PMID:37238934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10215223/
Abstract

Hip fractures are a major health concern, particularly for older adults, as they can reduce life quality, mobility loss, and even death. Current evidence reveals that early intervention is recommended for endurance in patients with hip fractures. To our knowledge, preoperative exercise intervention in patients with hip fractures remains poorly researched, and no study has yet applied aerobic exercise preoperatively. This study aims to investigate the short-term benefits of a supervised preoperative aerobic moderate-intensity interval training (MIIT) program and the added effect of an 8-week postoperative MIIT aerobic exercise program with a portable upper extremity cycle ergometer. The work-to-recovery ratio will be 1-to-1, consisting of 120 s for each bout and four and eight rounds for the pre- and postoperative programs, respectively. The preoperative program will be delivered twice a day. A parallel group, single-blinded, randomized controlled trial (RCT) was planned to be conducted with 58 patients each in the intervention and control groups. This study has two primary purposes. First, to study the effect of a preoperative aerobic exercise program with a portable upper extremity cycle ergometer on immediate postoperative mobility. Second, to investigate the additional effect of an 8-week postoperative aerobic exercise program with a portable upper extremity cycle ergometer on the walking distance at eight weeks after surgery. This study also has several secondary objectives, such as ameliorating surgical and keeping hemostatic balance throughout exercise. This study may expand our knowledge of preoperative exercise effectiveness in hip fracture patients and enhance the current literature about early intervention benefits.

摘要

髋部骨折是一个重大的健康问题,尤其对于老年人来说,因为它们会降低生活质量、导致行动能力丧失,甚至危及生命。目前的证据表明,对于髋部骨折患者,建议进行早期干预以提高耐力。据我们所知,针对髋部骨折患者的术前运动干预研究仍然很少,且尚无研究在术前应用有氧运动。本研究旨在探讨在便携式上肢功率自行车测力计辅助下,术前进行有监督的中等强度有氧运动间歇训练(MIIT)计划的短期益处,以及术后8周MIIT有氧运动计划的附加效果。工作与恢复比例为1比1,每次运动持续120秒,术前和术后计划分别进行4轮和8轮。术前计划每天进行两次。计划进行一项平行组、单盲、随机对照试验(RCT),干预组和对照组各纳入58例患者。本研究有两个主要目的。第一,研究使用便携式上肢功率自行车测力计进行术前有氧运动计划对术后即刻行动能力的影响。第二,调查使用便携式上肢功率自行车测力计进行术后8周有氧运动计划对术后8周步行距离的附加效果。本研究还有几个次要目标,例如改善手术情况以及在整个运动过程中保持止血平衡。本研究可能会扩展我们对髋部骨折患者术前运动效果的认识,并丰富有关早期干预益处的现有文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/065f/10215223/301c16221ead/biomedicines-11-01263-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/065f/10215223/301c16221ead/biomedicines-11-01263-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/065f/10215223/301c16221ead/biomedicines-11-01263-g001.jpg

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本文引用的文献

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Protective Effects of Higher Exposure to Aspirin and/or Clopidogrel on the Occurrence of Hip Fracture among Diabetic Patients: A Retrospective Cohort Study.较高剂量阿司匹林和/或氯吡格雷对糖尿病患者髋部骨折发生的保护作用:一项回顾性队列研究
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Determinants of Six-Minute Walk Distance in Idiopathic Pulmonary Fibrosis and Idiopathic Pleuroparenchymal Fibroelastosis.
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