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酒精中毒及戒断对下丘脑神经激素和下丘脑外神经递质的影响。

The Effects of Alcohol Intoxication and Withdrawal on Hypothalamic Neurohormones and Extrahypothalamic Neurotransmitters.

作者信息

Simon Balázs, Buzás András, Bokor Péter, Csabafi Krisztina, Ibos Katalin Eszter, Bodnár Éva, Török László, Földesi Imre, Siska Andrea, Bagosi Zsolt

机构信息

Department of Pathophysiology, Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis Str. 1, 6720 Szeged, Hungary.

Department of Traumatology, Albert Szent-Györgyi Medical School, University of Szeged, 6720 Szeged, Hungary.

出版信息

Biomedicines. 2023 Apr 27;11(5):1288. doi: 10.3390/biomedicines11051288.

DOI:10.3390/biomedicines11051288
PMID:37238959
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10215965/
Abstract

The aim of the present study was to determine the effects of alcohol intoxication and withdrawal on hypothalamic neurohormones such as corticotropin-releasing factor (CRF) and arginine vasopressin (AVP), and extrahypothalamic neurotransmitters such as striatal dopamine (DA), amygdalar gamma aminobutyric acid (GABA), and hippocampal glutamate (GLU). In addition, the participation of the two CRF receptors, CRF1 and CRF2, was investigated. For this purpose, male Wistar rats were exposed to repeated intraperitoneal (ip) administration of alcohol every 12 h, for 4 days and then for 1 day of alcohol abstinence. On the fifth or sixth day, intracerebroventricular (icv) administration of selective CRF1 antagonist antalarmin or selective CRF2 antagonist astressinB was performed. After 30 min, the expression and concentration of hypothalamic CRF and AVP, the concentration of plasma adrenocorticotropic hormone (ACTH) and corticosterone (CORT), and the release of striatal DA, amygdalar GABA, and hippocampal GLU were measured. Our results indicate that the neuroendocrine changes induced by alcohol intoxication and withdrawal are mediated by CRF1, not CRF2, except for the changes in hypothalamic AVP, which are not mediated by CRF receptors.

摘要

本研究的目的是确定酒精中毒和戒断对下丘脑神经激素（如促肾上腺皮质激素释放因子（CRF）和精氨酸加压素（AVP））以及下丘脑外神经递质（如纹状体多巴胺（DA）、杏仁核γ-氨基丁酸（GABA）和海马谷氨酸（GLU））的影响。此外，还研究了两种CRF受体CRF1和CRF2的参与情况。为此，将雄性Wistar大鼠每12小时腹腔注射一次酒精，持续4天，然后戒酒1天。在第5天或第6天，进行脑室内（icv）注射选择性CRF1拮抗剂安他敏或选择性CRF2拮抗剂阿斯特辛B。30分钟后，测量下丘脑CRF和AVP的表达和浓度、血浆促肾上腺皮质激素（ACTH）和皮质酮（CORT）的浓度以及纹状体DA、杏仁核GABA和海马GLU的释放。我们的结果表明，酒精中毒和戒断引起的神经内分泌变化是由CRF1介导的，而非CRF2，不过下丘脑AVP的变化不是由CRF受体介导的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a7a/10215965/830f71d48389/biomedicines-11-01288-g013.jpg
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