心脏疾病中的线粒体功能障碍及治疗策略
Mitochondrial Dysfunction in Cardiac Diseases and Therapeutic Strategies.
作者信息
Huang Yafei, Zhou Bingying
机构信息
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, 167 North Lishi Road, Xicheng District, Beijing 100037, China.
出版信息
Biomedicines. 2023 May 22;11(5):1500. doi: 10.3390/biomedicines11051500.
Mitochondria are the main site of intracellular synthesis of ATP, which provides energy for various physiological activities of the cell. Cardiomyocytes have a high density of mitochondria and mitochondrial damage is present in a variety of cardiovascular diseases. In this paper, we describe mitochondrial damage in mitochondrial cardiomyopathy, congenital heart disease, coronary heart disease, myocardial ischemia-reperfusion injury, heart failure, and drug-induced cardiotoxicity, in the context of the key roles of mitochondria in cardiac development and homeostasis. Finally, we discuss the main current therapeutic strategies aimed at alleviating mitochondrial impairment-related cardiac dysfunction, including pharmacological strategies, gene therapy, mitochondrial replacement therapy, and mitochondrial transplantation. It is hoped that this will provide new ideas for the treatment of cardiovascular diseases.
线粒体是细胞内合成三磷酸腺苷（ATP）的主要场所，为细胞的各种生理活动提供能量。心肌细胞中线粒体密度很高，并且在多种心血管疾病中均存在线粒体损伤。在本文中，我们结合线粒体在心脏发育和体内平衡中的关键作用，描述了线粒体心肌病、先天性心脏病、冠心病、心肌缺血-再灌注损伤、心力衰竭和药物性心脏毒性中的线粒体损伤。最后，我们讨论了目前旨在减轻与线粒体功能障碍相关的心脏功能障碍的主要治疗策略，包括药理学策略、基因治疗、线粒体替代疗法和线粒体移植。希望这将为心血管疾病的治疗提供新思路。
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