Suzuki Yukihisa, Kiyosawa Motohiro
Department of Ophthalmology, Japan Community Health Care Organization, Mishima General Hospital, Shizuoka 411-0801, Japan.
Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan.
Biomedicines. 2023 May 22;11(5):1502. doi: 10.3390/biomedicines11051502.
This study aimed to examine the relationship between diabetic retinopathy (DR) and systemic factors. We evaluated 261 patients (143 men, 118 women, aged 70.1 ± 10.1 years) with type 2 diabetes. All participants underwent a fundus examination, fundus photography using spectral domain optical coherence tomography (SD-OCT), and blood tests. For glycated hemoglobin (HbA1c) levels, the average and highest values in the past were used. We observed DR in 127 (70 men and 57 women) of 261 patients. Logistic regression analyses revealed a significant correlation between DR development and the duration of diabetes (OR = 2.40; 95% CI: 1.50), average HbA1c level (OR = 5.57; 95% CI: 1.27, 24.4), highest HbA1c level (OR = 2.46; 95% CI: 1.12, 5.38), and grade of diabetic nephropathy (DN) (OR = 6.23; 95% CI: 2.70, 14.4). Regression analyses revealed a significant correlation between the severity of DR and duration of diabetes ( = -6.66; 95% CI: 0.21, 0.39), average HbA1c level ( = 2.59; 95% CI: 0.14, 1.02), and severity of DN ( = 6.10; 95% CI: 0.49, 0.97). Logistic regression analyses revealed a significant correlation between diabetic macular edema (DME) development and DN grade (OR = 2.22; 95% CI: 1.33, 3.69). DN grade correlates with the development of DR and DME, and decreased renal function predicts the onset of DR.
本研究旨在探讨糖尿病视网膜病变（DR）与全身因素之间的关系。我们评估了261例2型糖尿病患者（143例男性，118例女性，年龄70.1±10.1岁）。所有参与者均接受了眼底检查、使用光谱域光学相干断层扫描（SD-OCT）的眼底摄影以及血液检查。对于糖化血红蛋白（HbA1c）水平，采用过去的平均值和最高值。我们在261例患者中的127例（70例男性和57例女性）中观察到了DR。逻辑回归分析显示，DR的发生与糖尿病病程（OR = 2.40；95%CI：1.50）、平均HbA1c水平（OR = 5.57；95%CI：1.27，24.4）、最高HbA1c水平（OR = 2.46；95%CI：1.12，5.38）以及糖尿病肾病（DN）分级（OR = 6.23；95%CI：2.70，14.4）之间存在显著相关性。回归分析显示，DR的严重程度与糖尿病病程（=-6.66；95%CI：0.21，0.39）、平均HbA1c水平（= 2.59；95%CI：0.14，1.02）以及DN严重程度（= 6.10；95%CI：0.49，0.97）之间存在显著相关性。逻辑回归分析显示，糖尿病黄斑水肿（DME）的发生与DN分级之间存在显著相关性（OR = 2.22；95%CI：1.33，3.69）。DN分级与DR和DME的发生相关，肾功能下降可预测DR的发生。
