Luzzi Simona, Baldinelli Sara, Fiori Chiara, Morelli Mauro, Gainotti Guido
Department of Experimental and Clinical Medicine, Polytechnic University of Marche, 60126 Ancona, Italy.
Neurologic Clinic, Azienda Ospedaliero-Universitaria delle Marche, 60126 Ancona, Italy.
Brain Sci. 2023 May 11;13(5):788. doi: 10.3390/brainsci13050788.
Semantic Variant of Primary Progressive Aphasia (svPPA) has often been considered as a loss of knowledge stored in semantic memory, but might also be due to a general disruption of mechanisms allowing the acquisition, storage, and retrieval of semantic memories. In order to assess any parallelism in svPPA patients between loss of semantic knowledge and inability to acquire new semantic information, we administered a battery of semantic learning tasks to healthy individuals and svPPA patients, where they were requested to learn new conceptual representations and new word forms, and to associate the former with the latter. A strong relation was found between loss of semantic knowledge and disruption of semantic learning: (a) patients with severe svPPA had the lowest scores in the semantic learning tasks; (b) significant correlations were found between scores obtained in semantic learning tasks and scores obtained in semantic memory disorders in svPPA patients.
原发性进行性失语的语义变异型（svPPA）通常被认为是存储在语义记忆中的知识丧失，但也可能是由于允许获取、存储和检索语义记忆的机制普遍受到干扰所致。为了评估svPPA患者在语义知识丧失和无法获取新语义信息之间是否存在任何平行关系，我们对健康个体和svPPA患者进行了一系列语义学习任务，要求他们学习新的概念表征和新的单词形式，并将前者与后者联系起来。结果发现语义知识丧失与语义学习障碍之间存在密切关系：（a）重度svPPA患者在语义学习任务中的得分最低；（b）在svPPA患者中，语义学习任务得分与语义记忆障碍得分之间存在显著相关性。
